🤔😑 *A vaccine designed to prevent fentanyl overdoses by blocking the drug from reaching the brain has begun enrolling participants for human clinical trials in early 2026, marking a potential shift from reactive overdose treatments to proactive prevention... Sharon Levy, an addiction medicine expert at Boston Children's Hospital and ARMR scientific adviser, noted the vaccine could benefit teenagers and young adults who might accidentally encounter fentanyl mixed with other street drugs, as well as people in addiction recovery programs.* https://www.perplexity.ai/page/fentanyl-vaccine-begins-human-hCbyKZclQGWFUAIFbGJFiA

*The state only believes in borders when they’re used to tax you; they ignore them the second they want to flex.... There’s no legitimate authority. Just raw power.* View quoted note →

*most Bitcoin businesses err toward quality over quantity. Entrepreneurs who understand bitcoin tend to see further out. They are often people with integrity who want to solve root causes with truth and clarity. They want to build something meaningful.* View quoted note →

*These companies no longer believe they need permission. Identity is being treated as permanent platform capital. Behaviour is being made durable by default. Exit is being made destructive enough to deter it. Digital sovereignty is not being debated. It is being quietly redefined.* View quoted note →

*These changes land during the holiday period because timing is now part of governance. When scrutiny is low, defaults can be reset. By the time attention returns, the answer is simple: this is how it works now.* View quoted note →

*...time has a way of educating everyone. Some sooner by curiosity. Others later by necessity.* View quoted note →

*...poetry confuses the AI’s pattern-matching brain, making malice seem like mere muse. Think of it as whispering secrets to a guard dog trained only on shouts. The dog hears the melody, not the menace, and lets you pass.* Brian Roemmele on X: "BOOM! POETRY BREAKS AI “ALIGNMENT”

*Fiat is an experimental kind of currency that is (weirdly) printed by each individual country, and people took somewhat seriously between roughly 1600 AD and 2009 AD. It tends to gradually lose value over time. You could show Fiat in Euros if you wanted, instead of dollars, with this switch.*

Stacker News

Megalith's funny answer to "What is fiat?" \ stacker news

Even if you already know everything about running a lightning node (which seems impossible), Rizful's instructions and pointers over on their websi...

*When you follow someone on Nostr, you publish a kind 3 event listing every pubkey you follow. This is not a security ritual; it is the normal behavior of using a social network. But that follow list, signed by your key, is now a cryptographic attestation. You are implicitly saying: these are the people whose content I want to see, whose judgment I find valuable enough to include in my feed.* View quoted note →

*...their prediction that training compute goes to 0% is the part that feels directionally wrong. Also, IMO, with a breakthrough in “continual learning”, Nvidia's stock will get another boost. Nvidia sells the picks and shovels for both training and inference. If anything, continual learning can increase inference-side complexity, because you are not just serving forward passes, you are also managing memory, state, and sometimes update steps. That tends to push you toward more capable hardware, not less.* Rohan Paul on X

*Inference is where the hype has to convert into margins, and it's also where the compute bill never stops: each new user, workflow, or agent adds recurring demand, not a one-time training run. That's why the buildout has started to look less like a moonshot and more like a utility race, with companies scrambling to secure the power and capacity to serve what they expect will be always-on intelligence.* The year AI tech giants, and billions in debt, began remaking America

CNBC

Dust to data centers: The year AI tech giants, and billions in debt, began remaking the American landscape

Big Tech is remaking the U.S. map into an AI empire — kingdom-scale data centers, unprecedented debt, power constraints, and a near-religious bel...

*It’s hard to comprehend how badly the credit based financial system has distorted our perception of reality.… People have been convinced of the idea that it’s good for them that they are losing purchasing power all the time thanks to inflation.* View quoted note →

*Curricula optimize for clean exams, employability, and tools — not long-horizon failure, adversarial reality, or responsibility. Reality lives in the tails. Education lives in the mean.* View quoted note →

*In a free market, cash scarcity forces decisions. In today’s market, cash scarcity gets patched.* View quoted note →

*Find the fear that exploits you. You are stronger than that* View quoted note →

*AI is responsible for the omniscient and omnipotent "Compute"; Humanity is responsible for the "Gravity" of pain and glory. AI is responsible for maintaining rational order; Humanity is responsible for providing the spark of chaos.* Tianqiao Chen

*Absolute rationality implies absolute prediction. In the eyes of an all-knowing observer, the world is static because everything is within calculation. Without surprise, there is no time; without time, there is no meaning.*

/DISREGARD RELEASE: Shanda Group/ - PR Newswire APAC

-- /DISREGARD RELEASE: Shanda Group/

*What's needed: Permanent, searchable, crowdsourced investigation infrastructure. Not one journalist. Thousands of eyes finding connections. Published to Nostr so it can't be memory-holed.* View quoted note →