"Tetrazole derivatives have featured several times here in "Things I Won't Work With", which might give you the impression that they're invariably explosive. Not so - most of them are perfectly reasonable things. A tetrazole-for-carboxyl switch is one of the standard med-chem tricks, standard enough to have appeared in several marketed drugs. And that should be recommendation enough, since the FDA takes a dim view of exploding pharmaceuticals (nitroglycerine notwithstanding; that one was grandfathered in). No, tetrazoles are good citizens. Most of the time."
... "The paper mentions that "Introducing N-oxides onto the tetrazole ring may . . . push the limits of well-explored tetrazole chemistry into a new, unexplored, dimension.""
... "And it makes for quite a party tray: the resulting compounds range from the merely explosive (the guanidinium salts) to the very explosive indeed (the ammonium and hydroxyammonium ones). They checked out the thermal stabilities with a differential scanning calorimeter (DSC), and the that latter two blew up so violently that they ruptured the pans on the apparatus while testing 1.5 milligrams of sample."
... "In the immortal words of a former PFE research director, "So, vee are actually making zees kompounds on purpose?""
👉🫨💥
#chemistry #lol #lmao #ohshit
Fixing the ills of society requires a somewhat broad agreement on what the ills of society are, in the first place. If this is not possible to achieve, politics becomes a perpetual battleground of trying to hammer square blocks into the round holes of your neighbours, and taking turns at it every four years, in the end by any means possible.
#politics
Finding #books for sale named "The Metaverse and how it will revolutionize everything".
Yeah, the Metaverse... The thing they made Mark Zuckercunt rename Facebook to Meta, spend several billion dollars making VR environments where people had no legs, and finally silently bury the whole thing when AI became the next hot topic.
That thing. #lol