Jerry Jones reported that he had a fatal cancer diagnosis several years ago, with tumors in his lymph nodes and he took an experimental drug called PT1, which cured him of his cancer. Here is a summary. PT1 is a small-molecule activator of AMPK (AMP-activated protein kinase). AMPK is a key energy sensor in cells that regulates cellular metabolism, especially under stress conditions like nutrient deprivation or hypoxia—common features in tumors. Mechanism of Action in Cancer * Activation of AMPK: * PT1 directly binds to and activates AMPK. * Activation of AMPK can inhibit mTOR (mammalian target of rapamycin), a pro-growth pathway often upregulated in cancer cells. * Inhibition of mTOR Signaling: mTOR is involved in cell growth and survival. Its inhibition suppresses tumor growth and proliferation. * Induction of Autophagy: * AMPK activation can lead to autophagy (cellular self-digestion), which can be either pro-survival or pro-death depending on context. * In cancer therapy, autophagy can limit cancer cell survival under stress. * Modulation of Cellular Metabolism: PT1 may shift cancer cell metabolism from anabolic (growth-promoting) to catabolic (energy-conserving), reducing cancer cell proliferation. * Possible Pro-apoptotic Effects: By altering survival signaling, PT1 may sensitize cancer cells to apoptosis (programmed cell death). Natural AMPK Activation Strategy 🥼 1. Core Supplement Stack * Berberine, 500 mg, 2× daily (before meals). Avoid taking it with other medications (can affect absorption/metabolism). Mimics metformin. * EGCG (Green Tea Extract), 300–400 mg, 1× daily (with or without food). Use decaffeinated if sensitive. Avoid combining with iron-rich meals. * Resveratrol (Trans-resveratrol), 150–250 mg, 1× daily (with fat-containing meal). Enhances SIRT1 and AMPK; low bioavailability, so take with fat or liposomal form. * Quercetin, 500 mg, 1× daily (with food). Helps with inflammation and oxidative stress. Consider stacking with vitamin C for absorption. Cycle supplements every few weeks to avoid tolerance and support long-term effectiveness. 🥗 2. AMPK-Boosting Diet ✅ Emphasize: * Low-glycemic, anti-inflammatory foods * Fasting-mimicking patterns * Colorful vegetables (polyphenols: quercetin, sulforaphane, curcumin) * Healthy fats (avocados, olive oil, nuts) * Fermented foods (gut–immune–cancer axis) 🚫 Limit: * Refined carbs & sugar * Processed meats and trans fats * Constant snacking (disrupts AMPK cycles) ⏳ 3. Intermittent Fasting (IF) or Time-Restricted Eating (TRE) * 16:8, Fast 16 hrs, eat during 8-hour window (e.g., 12pm–8pm). Boosts AMPK, lowers insulin, improves autophagy * 5:2, Eat normally 5 days, restrict calories 2 days/week. Activates AMPK, reduces inflammation * 24-hr fast, Once per week/month (under supervision). Deep autophagy and AMPK activation * 💡 Even skipping breakfast and eating from 12–8pm can help. 🏃‍♀️ 4. Exercise to Activate AMPK AMPK is highly sensitive to energy stress—exercise is one of the best natural activators. * High-intensity interval training (HIIT) – short bursts of intense effort * Resistance training – depletes glycogen, increases AMPK * Zone 2 cardio – enhances mitochondrial health (brisk walking, cycling) * 🧠 Bonus: Physical activity improves immune surveillance against tumor cells. 😴 5. Sleep, Stress, and Recovery Chronic stress and poor sleep impair AMPK signaling. * Prioritize 7–9 hours of quality sleep * Reduce chronic cortisol levels (meditation, breathwork, nature walks) * Consider magnesium, ashwagandha, or L-theanine if stress/sleep is a problem

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I wouldn't be averse to using more double negatives in conversation