Dr Sam Soete

Decentralized Health & Decentralized Wealth This Is The Way

Reclaiming sovereignty over my life was one of the core reasons (there are many) to leave the conventional medical system and setup a decentralized health optimisation practice. Sure, sometimes I still work 10-12hr days, but yesterday for example the sun was shining and I spent the morning getting raw milk and eggs at the farm, called an old friend while walking around in the garden, did client work in the early afternoon, then went for a cycle to a nearby calisthenics park + swim in the sea. I struggled to live a life where others constantly told me what to do and when to do it, dictated what I could and could not say. I can still work hard and find purpose in my work, but I can also choose to prioritize sunlight and sea swims when the weather commands it.

Centralized medicine is focused on blood sugar and insulin levels. Decentralized health focuses on what your cells are able to do with that fuel! It looks into mitochondrial function and metabolism. One optimises for markers that are easily measured, then prescribes drugs to shove glucose into cells, but does nothing to help the mitochondria that are already struggling - that is why cells aren't accepting insulin in the first place.

My testosterone was 1138ng/dl (2024, retesting soon). *Yes I will actually show you some receipts. So what do I do? - Optimize sleep (9pm-5am +1-2hrs in winter) - Maximised sunlight exposure especially UV - Kept my circadian rhythms in sync - Micronutrient dense diet (animal based) - Exercised consistently - Built a healthy amount of lean muscle mass - Avoided xenoestrogens as much as possible - Daily grounding as much as possible - Believed in my often contrarian viewpoints despite mainstream ideology The fundamentals are what matter. Always. This is the way.

Visual anagrams. Coolest thing I've seen today . https://blossom.primal.net/5fcec5f565e07a403b9cc85cc83aeac7e67739b12a8a1a9d6e763b72a7531c0c.mp4

If you don't make beta endorphins from the sun and moving your body, it will seek opioid substances elsewhere.

Thiamine requires magnesium to be activated to TPP.

Drivers of Thiamine Deficiency 1. Dietary Choices - Refined sugar and carbohydrates - White rice intake (polished rice) - Processed foods - Frequent alcohol consumption 2. Poor Absorption - Chronic gut issues (SIBO, IBD) - Thiamine inhibitors (coffee, tea, raw fish) - Medications (metformin/ diuretics for example) -General digestive impairment 3. Increased Losses - Kidney disease - Diabetes -Diarrhea or chronic loose stools - Vomiting 4. Increased Demand - Excessive exercise - Surgery or infection - Pregnancy and lactation - Hyperthyroidism - High carbohydrate diet 5. Oxidative Stress - Impaired antioxidant system - Environmental Toxicities

Gm

On the importance of spontaneous curiosity & exploration. "I wonder what's over that hill over there..." "Where does this little path lead to..." When this feeling arises, follow it. Always follow it. Its the path to adventure. Where side quests are found. This is what humans are built for. This is our niche.

My dad always told me I couldn't escape society or its rules. Im doing my best to prove him wrong.

The microbiota target mitochondria to regulate their interaction with us. If this signalling is imbalanced that will result in a mito dysfunction -> cellular dysfunction. We know that short chain fatty acids have beneficial effects on mitochondrial activity. Gut health drives healthy mitochondria and the two cannot be separated. This is the holobiont perspective. Systems upon systems.

If you want freedom, you have to take control of your health. It is foundational.

Gm

You will be given a vitamin D supplement, which will raise your LDL, then they will give you a statin, which will impair your mitochondria, then you will be given metformin, duloxetine or pregabalin, and on the cycle goes. Really, all you needed was some sun.

We are scared of the wrong things. We fear alienation. We fear not fitting in. We fear criticism, embarrassment and failure. How about the idea that we have less than 5000 weeks on this earth? 5000 weeks to do something worthy of the gift of life. This is the way.

What happens to your ability to uncouple your mitochondria and burn of excess calories or regulate temperature when you are on statins and develop a CoQ10 deficiency?

𝗠𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 𝘄𝗶𝗹𝗹 𝘄𝗼𝗿𝗸 𝘀𝘂𝗯-𝗼𝗽𝘁𝗶𝗺𝗮𝗹𝗹𝘆 𝗶𝗳: 1. They receive the wrong fuel (light & food mismatch) 2. Are deficient in key building blocks (CoQ10, B vitamins, Mg, Cu, Zn, Se, fats, etc.) 3. Inhibited by toxins (antibiotics, heavy metals etc.) 4. Levers pulling on mitochondrial function are impaired (thyroid function for example)

No words needed.

Butyrate is a mitochondrial nutrient. But its never mentioned alongside CoQ10, PQQ, B vitamins, etc. 1) Direct fuel source Colonocytes preferentially use it as their main energy substrate. Butyrate enters mitochondria and undergoes β-oxidation → acetyl-CoA → TCA cycle → ATP. Brr.. Very nice. 2) Epigenetic regulation Butyrate inhibits histone deacetylases or HDACs. Learnt this from mr Greg. This changes gene expression in ways that upregulate mitochondrial biogenesis (via PGC-1α, NRF1/2) and antioxidant defenses. 3. Redox balance Butyrate metabolism increases NADH and FADH2 supply to the ETC. 4. Anti-inflammatory signaling Really interested in this one regards to CDR. By dampening NF-KB and upregulating Nrf2 pathways, it reduces chronic inflammation and returns mitochondrial prioritisation to energy production. 5. Mitochondrial quality control Butyrate might also promote mitophagy and fusion/fission dynamics so that lowers heteroplasmy.