Do you have to fiddle with the os to get it work with apps and programs that you use?
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Define fiddle, you add whatever you need to a configuration dot nix and `sudo nixos-rebuild switch`. Any issues you can role back at startup. Its very simple. Here's my day-to-day. All I need do is pull that into a new machine and boom, all apps I use installed. 
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nixos/configuration.nix at master · arcbtc/nixos
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