You can use the username as a short link to your profile outside of Nostr: iris.to/mattoso
NIP05 is just extra feature of the username. You can use it or use some other NIP05 if you have many.
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I ask because I created a username on iris and then changed the NIP-05 address on my profile and my previously registered iris.to/username was said to be "available" when I opened iris.to from a "new" browser and tried to register it again with a "new" private key.