I've stopped using it as my daily driver. I found version upgrades required quite an investment in time and their perfered approach to declarative config kind of sucks. I now use nixos and i try and compartmentalise as much as possible.

GitHub

GitHub - CertainLach/nixos-qubes: QubesOS packages and dom0 for NixOS

QubesOS packages and dom0 for NixOS. Contribute to CertainLach/nixos-qubes development by creating an account on GitHub.

looked really promising and it looked like they were making a lot of progress really quickly but they seem to have abandoned the project 9 months ago.