It's fine if you don't accept 0-conf. Not running it consumes significantly more bandwidth now because 95% of miners run it so your node is constantly having to reconstruct blocks after they are mined.

GitHub

policy: enable full-rbf by default by 1440000bytes · Pull Request #30493 · bitcoin/bitcoin

This pull request enables full rbf (mempool policy) by default. #28132 was closed recently with this comment. Rationale: Full RBF config option ...