Also, have you ever looked at

Media over QUIC

Media over QUIC is a new live media protocol designed for simplicity and scale. It uses new browser technologies like WebTransport and WebCodecs to...

? I think it could be a really nice alternative to webrtc. It's far simpler and flexible. The best demo I made using it was https://github.com/justinmoon/av-demo. This does uses Marmot/Whitenoise encryption stack on audio calls. I think this would be a really nice stack for nostr a/v work. Happy to collaborate if you're interested!

The signaling layer runs over NIP-100, where events are delivered via GiftWrapped messages. Media streams are protected using WebRTC’s e2e encryption (SRTP).