the hardest thing to do is shatter your own ego

there are countless reports of people not burning at all or very little when cutting seed oils out of their diet. how could this be? my hypothesis: Linoleic acid (the main fatty acid in seed oils) is bacteriostatic and bactericidal (deadly) to small intestinal lactobacillus

Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids | eLife

Lactobacillus johnsonii helps stabilize the skin’s resilience to UV damage

JDDonline - Journal of Drugs in Dermatology

Exploring the Gut Microbiome's Role in Drug-Induced Photosensitivity: A Need for Deeper Investigation - JDDonline - Journal of Drugs in Dermatology

INTRODUCTION Drug-induced photosensitivity is an adverse reaction to ultraviolet (UV) radiation triggered by medications like antibiotics, nonstero...

so if disruption of gut flora by excessive pufa and linoleic acid causes a loss of the gut's protective effects on the skin, then seed oils could very well contribute to ease of sunburning

when you think about biology from first principle and you learn that almost 9% of variants are as a result of in silicon processing of base pairs you begin to wonder if our induction of the sub microscopic world is correct

PubMed

Choice of assemblers has a critical impact on de novo assembly of SARS-CoV-2 genome and characterizing variants - PubMed

Our analyses indicate the critical role of assembly methods for assembling SARS-CoV-2 genome using short reads and their impact on variant characte...

Meta-analysis says low LDL cholesterol may be associated with greater risk of cancer - PMC

your body needs cholesterol for cellular health and there is an inverse relationship with cancer and low ldl. more cancer incidence with low ldl

Loom

Join Us for the Inaugural Park Forum: The Case for Bitcoin in Healthcare! 🚀

Hey everyone, I'm excited to invite you to our inaugural Park Forum, 'The Case for Bitcoin in Healthcare,' happening on April 8th in Nashville, coi...

The Case for Bitcoin in Healthcare April 8 in Nashville

imagine there was an environmental thing where intermittent exposure increased cancer risk but continuous exposure was not associated (and maybe inversely associated) with cancer risk. what would you conclude? that you should avoid it or spend as much time around it as possible? that thing is sun

Occupational sun exposure and risk of melanoma according to anatomical site - PMC

Although sunburn and intermittent sun exposures are associated with increased melanoma risk, most studies have found null or inverse associations b...

if you have a ton of data, personal or business there is no reason you don't build your own RAG system. it is very very cheap and gives you universal personal search.

feynman on new ideas: you may feel overwhelmed and just want some peace to sit and come up with something wonderful...but there's a better chance that the stress and chaos is what you need for your good idea to take shape best way to get that chaos and questioning everyday is to just have some kids. soon you will have more ideas than you have time.

ketosis is a survival mechanism, it is not a physiologically normal way to live for weeks on end.

The only problem with peer review is the fact almost all studies keep their raw data private --the peer reviewers rarely see the data and when the study is published, the data remains private. there's no need for peer review if every study just publishes raw data -- then anyone can evaluate whenever they want

mortality trends for classic vaccines

Terry Godier

The Last Quiet Thing

Your possessions came alive. Now they won't stop talking.

tools should be predictable and only draw our attention when they are needed.

definitely a classic influencer post but for some people worth a try. removing the social media apps is probabaly the biggest win for most people. no social media, no need for a phone.

creatine use for nicotine cessation: Only have anecdotal evidence to support this in a handful of people who were all hooked on zyn pouches Smokers had lower concentrations creatine in the medial prefrontal cortex compared to nonsmokers

PubMed

Daily and intermittent smoking are associated with low prefrontal volume and low concentrations of prefrontal glutamate, creatine, myo-inositol, and N-acetylaspartate - PubMed

Cigarette smoking is still the largest contributor to disease and death worldwide. Successful cessation is hindered by decreases in prefrontal glut...

https://www.nature.com/articles/s41380-023-02247-0 creatine supplementation increases brain levels

“Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function | Sports Medicine | Springer Nature Link

There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and function. Creatine...

nicotine lowers brain creatine → low brain creatine may impair prefrontal function and self-regulation → creatine supplementation might restore those levels and support cognitive function during withdrawal

two good review articles on the harms of food dyes 1.

PubMed

Toxicology of food dyes - PubMed

This review finds that all of the nine currently US-approved dyes raise health concerns of varying degrees. Red 3 causes cancer in animals, and the...

2. https://www.sciencedirect.com/science/article/abs/pii/S0924224425002213 Children are considered especially vulnerable due to their lower body weight (they get a greater weight based dose in a day) Production of Red 40, Yellow 5, and Yellow 6 leaves behind contamination with benzidine and other carcinogens. Dyes have been associated with a colitis, renal insufficiency, hepatotoxicity, pathological changes in the gut, and oxidative stress.

the joy you get from seeing your children try something new and want to keep at it to get better supersedes all possible happiness your might get from work or material accolades

Reason.com

The tax loophole that made U.S. health care unaffordable

The core structural problem of the health care market is simple: The person receiving care is almost never the person actually paying for it.

the exclusion of employer-sponsored health insurance from taxable income has had unintended consequences (as most gov programs do)

absence of evidence ≠ evidence of absence

just started reading this. very good so far

research institutions and professional schools are forced to use high priced research software with terrible UIs because the market is a niche without any competition now with the cost of software approaching zero the people can make useful tools that respect privacy and costs. introducing papertrace.org

PaperTrace.org

PaperTrace.org - We Organize Your Department

Track and organize your department