i exclusively wear altra running and vivo barefoot shoes wide toe box always

pretty good summary of all of the great knowledge that emerged (and has been been forgotten) from the Swedish-Amoris study https://ecancer.org/en/journal/article/555-metabolic-serum-biomarkers-for-the-prediction-of-cancer-a-follow-up-of-the-studies-conducted-in-the-swedish-amoris-study/pdf most summary articles still interpret the findings from the lens of lipids and glucose synergistically drive risk risk rather than glucose drives lipid pathology and also drives cardiovascular and cancer risk

the swedish amoris (Apolipoprotein-related MOrtality RISk)

How it all started

The AMORIS (Apolipoprotein-related MOrtality RISk) cohort includes subjects who underwent health examinations during the period 1985-1996 and where...

https://www.researchgate.net/publication/313385633_The_AMORIS_cohort

PubMed

The interplay between lipid profiles, glucose, BMI and risk of kidney cancer in the Swedish AMORIS study - PubMed

With exception of cholesterol and total fat intake, associations between lipid biomarkers and kidney cancer have not often been researched. We aime...

this landmark study showed how elevated blood glucose levels are driving the pathology that is associated with cholesterol. when humans have normal blood glucose their body thrives off of cholesterol and when they have diabetes, cholesterol becomes fuel for their internal derangements

wishing everyone on this protocol a happy 2026. has been wonderful fun creating posts for you all

it is great to see research focusing on the metabolic cause of alzheimer's. NAD+ issues relate to the mitochondria dysfunction that occurs after years of metabolic dysfunction. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1 i think for now the best everyone can do is get their fasting insulin down below 7 and take creatine daily

Creatine as a Therapeutic Target in Alzheimer's Disease - PMC

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, affecting approximately 6.5 million older adults in the United States. De...

if you do take a vitamin d supplement always consume it with K2 and best to just get it from sunlight and liver (has natural k2 to vitamin d3 ratio) otherwise taking vitamin d3 in isolation overwhelms you body with sequestered calcium

the animal based nutritional research foundation is doing wonderful research

Give Today, Transform Tomorrow: Fueling a Radical 2026 | Animal Based Nutrition Research Foundation (Powered by Donorbox)

Your support directly powers the independent research, education, and community-building that the Animal-Based Nutrition Research Foundation is lea...

this is @Paul Saladino MD organization and i owe him a lot of gratitude for his original carnivore book that opened my eyes to the ancestral animal based diet we forgot in the modern age. before that i floundered with plant based diets and all the standard teachings of medical school vilifying cholesterol and pushing vitamin supplements.

vitamin D has never been isolated from humans in a form distinct from vitamin D₃ (cholecalciferol). In humans, only vitamin D₃ has been identified This compound is produced in the skin when 7‑dehydrocholesterol is irradiated by UV‑B light. The term "vitamin D₁" was initially used but was later discovered to be an artifact—a mixture of vitamin D₂ and another compound The first pure vitamin D to be isolated and identified was vitamin D₂ (ergocalciferol), but this was from plant/fungal sources (like irradiated yeast), not from humans

100 YEARS OF VITAMIN D: Historical aspects of vitamin D - PMC

Vitamin D has many physiological functions including upregulation of intestinal calcium and phosphate absorption, mobilization of bone resorption, ...

History of the discovery of vitamin D and its active metabolites - PMC

Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher a...

great sci fi books i've read over the last few years: Delta-V by Daniel Suarez Kill Decision by Daniel Suarez Daemon by Daniel Suarez Freedom TM by Daniel Suarez Nexus by Ramez Naam Silo Series by Hugh Howey Sand Chronicles by Hugh Howey Project Hail Mary, by Andy Weir All Systems Red, by Martha Wells Recursion, by Blake Crouch The Long Way to a Small, Angry Planet, by Becky Chamber Red Rising, by Pierce Brown Exhalation, by Ted Chiang We Are Legion, by Dennis E. Taylor Children of Time, by Adrian Tchaikovsky

Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies - PMC

Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent stud...

glyphosate, the world's most widely used herbicide, inhibits CYP enzymes -- the very enzymes we need to synthesize vitamin D from sunlight and cholesterol

some hidden truths about vitamin d3 supplements (Cholecalciferol) (it is an active ingredient in rat poison) The hormone form of D signals your intestines to preferentially absorb calcium over magnesium. Magnesium is anti-inflammatory; calcium is inflammatory D3 from wool which is coated in lanolin (sebaceous gland secretions)gets washed with industrial detergents. The extracted lanolin then undergoes a "dehydrobromination reaction" using either 2,4,6-trimethylpyridine (derived from coal tar) or a cocktail of sodium hydroxide, potassium hydroxide, N-Bromosuccinimide, and chloroform. D3 toxicity typically requires doses above 10,000 IU daily for months when you get your "vitamin D" level checked the lab is testing for the presence of synthetic markers – specifically, they're measuring 25-hydroxyvitamin D, which is what your liver creates from cholecalciferol. The Inuit, living in darkness for months, eating a diet of seal and whale – no rickets, no vitamin D deficiency. Traditional cultures worldwide, no access to supplements, no fortified foods, yet no epidemic of bone diseases.

i really like this flu study. what causes the flu in equator level counties if it isn't from the cold, isn't from being indoors on a seasonal basis and isn't from changes in relative humidity "Through this, we show that influenza in Vietnam does not show consistent timings, making preparedness efforts such as vaccination campaigns difficult to design." https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011317

this is the explanation for why the flu is seasonal: 1. Viral Stability in Cold, Dry Air: Influenza viruses survive better and remain in the air longer when the air is cold and dry. Low absolute humidity (the total amount of water vapor in the air, which is lower in winter even when relative humidity is high) allows the tiny respiratory droplets that carry the virus to stay suspended for longer periods and travel farther. 2. Host Immune Response: Cold, dry winter air can also impair our innate immune defenses. The mucociliary clearance system, which is the layer of mucus and tiny hairs (cilia) in our respiratory tract that traps and clears out pathogens, works less efficiently in these conditions 3. Human Behavior: During colder months, people spend significantly more time indoors in closer proximity to one another. This increased crowding in homes, schools, and offices facilitates easier transmission of the virus through respiratory droplets and aerosols. does this sound logically coherent to you?

there are no conditions that would survive from an evolutionary perspective that severely disabled young people before having children. you should not be hearing about young adults and teenagers having strokes and heart attacks.

a common statement in infectious disease: "if something is highly infectious and not lethal it spreads far but highly lethal and infectious won't spread" ask yourself: if something kills a host very quickly and people learn to avoid that sick person so they don't immediately die, how does the "virus" continue to exist?

the best peer review is scientific experiment replication. if different groups do the same experiment over and over and get the same result there is no need for peer review. replication is the only valid peer review.

"This study found a significantly higher risk of influenza among the vaccinated compared to the unvaccinated state in northern Ohio during the high influenza activity period of the 2024-2025 influenza season." the vaccinated group showed a whopping 27% increased risk of contracting influenza in the months after vaccination, compared with the unvaccinated group

medRxiv

Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season: A Prospective Cohort Study

Background The purpose of this study was to evaluate the effectiveness of the influenza vaccine during the 2024-2025 respiratory viral season. Met...

the danger of proton pump inhibitors (ppi): PPI forms a covalent bond with your proton pumps and inhibit them until degenerated 72hra later. Your stomach pH goes from a highly acidic 1.5–2.0 to above 4.0 for most of the day G-cells in your stomach produce gastrin to produce more acid, but since the pumps are disabled, the stomach can’t restore normal acid levels. Stomach acid is required to cleave B12 from the proteins and with high pH the B12 won't get absorbed. Also magnesium and calcium and zinc absorption is affected. Stomach pH plays a role in converting non-heme iron (Fe3+) to the more absorbable ferrous form (Fe2+) which can't happen effectively at high pH Pepsinogen the inactive precursor to pepsin requires a low pH in order to break down protein so protein absorption is affected. Bacteria from your mouth and other areas can now colonize the upper GI tract since their growth is no longer inhibited by low pH Stomach acid inactivates C. diff spores, and PPI users have a higher risk of C. diff infection because more spores can survive to the intestines. Long-term PPI use is consistently associated with increased risk of hip and other bone fractures due to the mineral absorption issues.

Review of the Long-Term Effects of Proton Pump Inhibitors - PMC

Proton pump inhibitors are widely used, but up to 70% of patients take them without an appropriate indication and face risk of adverse effects asso...