most vitamin D3 (cholecalciferol) capsules are semisynthetic it is extracted from lanolin (sheep's wool). The lanolin contains 7-dehydrocholesterol, which is then exposed to UV light to convert it into Vitamin D3 (cholecalciferol) Some "vegan" Vitamin D2 (ergocalciferol) supplements are produced by exposing lichens to ultraviolet light. humans can store vitamin d in adipose tissue (fat soluble) for indefinite periods of time. The more time you get in the sun during the summertime the less likely you are to need any vitamin d in the winter regardless of where you live on the planet.

it is my prediction that we will find that metabolic dysfunction is at the heart of mild and severe dementia we can basically think of dementia as "diabetes of the brain". https://www.sciencedirect.com/science/article/pii/S1568163725000595

The thyroid produces mostly thyroxine (T4), which must convert to triiodothyronine (T3) — the active hormone. Polyunsaturated fatty (PUFAs) acids slow this conversion, possibly by: 1. Inhibiting 5’-deiodinase, the enzyme that converts T4 → T3 2. PUFAS also increasing oxidative stress in liver cells, which impairs normal metabolism 3. PUFAs and their oxidation products can bind to thyroid transport proteins or cell receptors, reducing how effectively T3 gets into cells. 4. Animal studies have shown that feeding high-PUFA diets can lower TSH output from the pituitary gland, slightly reducing thyroid stimulation.

super interesting epidemics study in mice: "Paternal exercise confers endurance capacity to offspring through sperm microRNAs" https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00388-2 male mice after being trained for endurance exercises showed expression of microRNAs in their sperm that increased mitochondrial synthesis in the next generation.

the soon and longer you read outloud to your children the better they will be in all aspects of life https://www.researchgate.net/profile/Juan-Mata/post/Can_you_help_me_finding_recent_studies_about_parental_involvement_in_reading/attachment/59d645bc79197b80779a0ceb/AS%3A454465254891521%401485364368305/download/ReadingAloudtoChildren_ADC_July2008.pdf i think the most under appreciated aspect is the ability to sit still and concentrate using their imagination at the same time.

if you can visit yellowstone in october, it is wonderful. not crowded with tons of wildlife

healthcare administrators are a product of the government management of healthcare. the amount of burden from accreditation agencies alone take half of these administrators and insurance makes up the rest @npub1sk7m...jraw

in medicine, it's much more acceptable to do what is recommended than to do what is true 

abs are made in the kitchen. discipline is made in the gym

just as AI is going to canibalize primary care where everyone has the insights to equal their "general doc", the AI powered self driving vehicle revolution is going to slowly eliminate motor vehicle accidents that provide the majority of volume at every trauma center

knowledge is the ability to do compression and then decompression on information in the world

knowledge is the ability to do compression and then decompression on information in the world

meat is nature's ozempic https://onlinelibrary.wiley.com/doi/pdf/10.1002/oby.20154

A good summary of acetaminophen use during pregnancy. The evidence is definitely concerning

PubMed

Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology - PubMed

Our analyses using the Navigation Guide thus support evidence consistent with an association between acetaminophen exposure during pregnancy and in...

Not a slam dunk but the higher quality the study, the more likely it is to show an association. Seems like there is probably a genetic component since sibling studies don't find an obvious association. If you can avoid acetaminophen use especially when young or pregnant it seems like an obvious no brainer.

the nice thing about "longevity" influencers is that their theories will be tested in an absolute way with time.

just got around to watching the liver king documentary. he was right about a lot. its such a shame that his message is now attached to his personality and lies.

just got around to watching the liver king documentary. he was right about a lot. its such a shame that his message is now attached to his personality and lies.

we are almost at the point where very few people need a primary care doc to do anything other than order them labs. The motivated patient who wants insights into their health just needs one large comprehensive baseline lab panel and access to an open source Ai model (i recommend kimi k2 or qwen2) to help interpret any of their results and guide them to correct any deviations from optimal health. Then yearly checks on subset of their labs to help check how their diet has impacted any issues. Using an open source model without you account (right now via @Maple AI or @PayPerQ) Ordering Docs right now serve as gatekeepers who will have to adapt to be experts in interpretation and guidance since their "knowledge" of human physiology is being widely and rightly distributed into the hands of the general public. One doc with the power of LLM tools can now help thousands of people manage their own health. If you pair that doc with a telemedicine practice they can help a community far outside of their local geography.

this is my #politics

there certainly seems to be an exercise and fitness culture here on #nostr if i could only do one exercise it would be the "L pull up" on rings