one of the best studies ever published Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment

PubMed

Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment - PubMed

Recent research has identified a unique population of 'Lean Mass Hyper-Responders' (LMHR) who exhibit increases in LDL cholesterol (LDL-C) in respo...

it is a surprising easy 5 step process to cure type 2 diabetes. the difficulty is getting people to follow all steps 1. drop body fat to less than 15% (intermittent fasting + animal diet) 2. remove polyunsaturated fat from diet and follow body composition changes via fatty acid panel 3. repair oxidative stress with gut flora restoration via pro/prebiotic + h2 supplementation 4. Lift heavy objects for 30min a day 3 days a week. 5. Sleep 8hrs a day

this is the recently popularized henry food vaccine study. it is a well done study that cannot show causation. at most it can show association... the biggest criticism is the difference in the populations in each group. if those differences contribute to chronic disease then no conclusion can be drawn about the exposure to vaccines https://www.hsgac.senate.gov/wp-content/uploads/Entered-into-hearing-record-Impact-of-Childhood-Vaccination-on-Short-and-Long-Term-Chronic-Health-Outcomes-in-Children-A-Birth-Cohort-Study.pdf

in order to show safety, studies should follow patients for long periods of time (to detect a link to chronic diseases or all cause mortality ) and should also use saline placebo that have no potential bioactivity View quoted note →

There unfortunately are no double blind randomized placebo controlled trials in clinical vaccine research. All of the trials use an "active" placebo for good reason. The adjuvent is probably the problem for humans not the innactivated dna/rna particle. Here is a list of placebos for vaccine trials: 1. HPV (Gardasil) Clinical Trial: Placebo was an aluminum adjuvant and the Hepatitis A vaccine. 2. Hepatitis A Clinical Trial: Placebo was the Hepatitis B vaccine. 3. Influenza A Clinical Trial: Placebo was the Influenza B vaccine. 4. Meningitis Vaccine Clinical Trial: Placebo was the DTaP (Diphtheria, Tetanus, and Pertussis) vaccine. 5. Pertussis Vaccine Clinical Trial: Placebo was the Diphtheria & Tetanus vaccine. 6. Prevnar-13 (Pneumonia) Clinical Trial: Placebo was the Prevnar-7 vaccine. 7. Hepatitis A Clinical Trial: Placebo was an aluminum adjuvant. 8. Prevnar-9 (Pneumonia) Clinical Trial: Placebo was the DTP-Hib vaccine. 9. Cholera Vaccine Clinical Trial: Placebo was the K-12 E.Coli vaccine. 10. Prevnar-23 (Pneumonia) Vaccine: Placebo was the Hepatitis A & B vaccines. 11. Polio Vaccine Clinical Trial: Placebo was a diluted polio vaccine. 12. Chicken Pox Vaccine Clinical Trial: Placebo was a diluted chicken pox vaccine. 13. Shingles Vaccine Clinical Trial: Placebo was a diluted shingles vaccine. 14. Some COVID-19 Vaccine Clinical Trials: Placebo was the Meningitis vaccine.

https://archive.is/9yGY1 "When the bill for the well visit came, my wife, who is her mother’s legal guardian, noticed two unfamiliar charges. One was a $150 “facility” fee. The other, for $40, was itemized as the “Evaluation and Management (E/M) add-on.” Almost $200 tacked on to a bill for a well visit. My wife isn’t one to tolerate being nickel-and-dimed. She wrote a polite note to the clinic inquiring as to the nature and purpose of the charges. Its reply is what irritated me. “The ‘Evaluation and Management (E/M)’ add-on is used to account for the complexity of E/M services that serve as the continuing focal point for all needed health care services or with medical care services that are part of ongoing care related to a patient’s single, serious condition, or a complex condition.” Verbatim. Because I work with words for a living, I am hard-wired to try to untangle sentences like this. My brain immediately begins breaking down the parts and reassembling them in a way that a person moderately familiar with the English language might find decipherable. I defy you to tell me what this blithering piffle actually means."

intermittent fasting is a great way to lose weight but not good to maintain weight or help with hormonal health. lose the weight with fasting. cut your fat with fasting. then dial in a good 1g/kg protein ingestion with moderate carbs and keep a good 10-15% body fat. avoid cheat days so your brain get used to "no binges"

@Kevin McKernan this is cute but all that matters is a DHT of your data. once the torrent is created and being seeded the data within it can't change. just release the data in a torrent and share a pdf anywhere you want. people will reanalyze the data as they wish and it is verifiable within the original torrent. put the pdf on a blossom server if you want

the online thing that matters in any scientific field, is the release of data. in physics a researcher does an experiment, explains the protocol writes very little about the results and releases the data which speaks for itself. in health sciences the opposite occurs. we describe the population/protocol, keep the data private, and then write endlessly about the statistical corrections necessary for interpretation. researchers should simple release all clinical data all the time for even the most trivial of retrospective studies (positive or negative). we don't need new journals, we need data repositories with attached data collection protocols. View quoted note →

it doesn't take rocket science to explain why children are obese. the problem is that the parents, teachers and "leaders" are also obese and the eating habits of children come from the adults "According to UNICEF, around 188 million schoolchildren and adolescents worldwide are obese, while only around 180 million are underweight"

Statista Daily Data

Infographic: For the First Time, More Schoolchildren Worldwide Are Obese Than Underweight

This chart shows the estimated proportion of underweight/overweight children and adolescents worldwide, by age group.

in clinical research there are so many observational studies that could be published if clinicians could structure all of their unstructured data. The retrieval-augmented generation (RAG) of LLMs finally allows for easy means of querying big sets of clinical text and results.

It seems likely that AI tools will help many people understand their lab results without needing to schedule follow ups. But, LLMs don't understand first principles they just predict the data patterns that they're given, Most of the data patterns are from the Internet with a lot of slop text. Training AI on historic data such as old print research from a time when it was expensive to write text so the text was high quality or old print newspapers, when it was expensive to print text so the ideas were high-quality would create the potential for language models to have high quality "reasoning".

there is a lot of great raw cheese made in the US, but for some reason the US parmesans are often pasteurized  View quoted note →

View quoted note →

it is estimated that just from 2016 to 2023 $51.4 billion has been spent in the "war against cancer" the war on cancer is similar to the war on homelessness. the more you spend the more the problem seems to grow.

pathogenic bacteria are on you and in you all day everyday yet you don't get sick. this is the terrain theory of disease. you are the terrain and when you create an unwell environment various organisms grow out of proportion and you get sick. keep your body in appreciate homeostasis and you are fine.

because of the mind body link, placebos are often more powerful than most drugs. i love this analysis of placebo for treating depression:

PubMed

Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants: A Systematic Review and Meta-analysis - PubMed

This study suggests that RCTs using PRI periods yield smaller within-group changes across both placebo and drug groups compared with RCTs without P...

placebos are 40% effective and drugs 54% effective, which means that 74% of the drug's effect is explained by the placebo effect.

"In 2016, journalist Del Bigtree issued a challenge to the head of infectious disease at one of the most prestigious medical institutions in the world: conduct the most thorough vaxxed vs. unvaxxed study that has ever been done. The expert took up the challenge and ran the study to prove Del wrong. That study never saw the light of day... until now."

An Inconvenient Study

WATCH NOW | An Inconvenient Study

An Inconvenient Study: This could change everything. An ICAN Production.

methylene blue is only useful if you have mitochondrial dysfunction. unfortunately there is no way to know if you have issues with your electron transport chain on the mitochondrial level. Most likely, people with many types of cancer and those with advanced dementia do have problems at the mitochondrial level but it is unfortunately trial and error to see if methylene blue produces any clinical effects. People with viral like illnesses also may have issues and experience benefits at low doses (<16mg/day). The problem arises when people use methylene blue like a stimulant because it does produce anti-depressent like effects (as a monoamine oxidase inhibitor). If you want an antioxidant, metheylene blue is not a good choice as it only works in one special place (complex III). You are better off drinking H2 water and getting direct reduction rather than anti-oxidation.