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Dr Sam Soete
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Decentralised Health Optimisation
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samsoete 1 week ago
Lets talk about the migrating motor complex (MMC) today. Your gut has a built-in cleaning system - it is key to optimizing gut health It's essentially a cyclical wave of contractions that sweeps through your stomach and small intestine every 90-120 minutes during the fasted state. Its job is to clear residual food particles, dead cells, mucus, and bacteria from the upper gut and push them toward the colon. This is how the small intestine maintains low bacterial density (music to the ears of those with SIBO/SIFO). When the MMC works, bacteria stay where they belong. When it doesn't, they accumulate and you get a bunch of downstream issues. The MMC has three phases. Phase I - Rest. Minimal contractions. The smooth muscle resets. Phase II - Irregular contractions building in intensity. Preparing for clearance. Phase III - High-amplitude rhythmic peristaltic contractions that sweep everything forward. This is the housekeeping wave. Phase III is initiated by motilin, a peptide hormone released during fasting (STOP GRAZING). Vagal tone and enteric nervous system integrity are required for proper coordination as well - B1, B5, choline, B6 are all key. But really what I want to focus on is this very simple practical fact that the body building community especially doesn't seem to realise. Eating shuts it off. Even small caloric inputs, especially carbs or protein, immediately suppress the MMC and switch the gut into fed-state segmentation contractions optimized for digestion. Every time you snack, the cleaning cycle resets. So if you're grazing all day, the MMC never completes. Bacteria aren't cleared = They migrate upward = SIBO develops. This is also why impaired MMC function shows up as more than just bloating. Constipation, acid reflux, bile reflux, that heavy fullness sensation after eating (which is abdominal distension, not gas production). Things that disrupt the MMC: - Frequent snacking/grazing - Chronic stress (↓ vagal tone) - Opioids (got some clients who developed SIBO from this most likely) - Anticholinergics - Post-infectious enteric nerve damage (you can test for this btw - anti-vinculin antibodies. - Circadian disruption. Things that support it - Consistent meal timing - Adequate fasting windows between meals (3-4+ hours) - Intact cholinergic signalling - Proper sleep-wake rhythms - Ginger maxxing
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samsoete 1 week ago
Anyone else feel like they have infinite energy running bare-chest, bare-foot on the beach by the water's edge? Is this the way? image
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samsoete 1 week ago
Gm, dont let rain/clouds stop you from going out for sunrise
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samsoete 1 week ago
If you wanna get sick as fast as possible, alter your sleep schedule by +/- 3hrs for 3 consecutive nights and understand the importance of circadian biology in the meantime
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samsoete 1 week ago
Raw egg yolks can single handedly solve certain gut issues related to PC deficiency and poor bile metabolism
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samsoete 1 week ago
Addressing a clients nervous system, nutrient deficiencies & acetylcholine production has led to improved sleep & recovery, eczema gone, dry eyes gone, workouts improved, more energy in the day.
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samsoete 1 week ago
Nutritional yeast is being slept on
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samsoete 1 week ago
Basic but often overlooked principle: The body’s need for nutrients goes waaaay up in acute & chronic illness
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samsoete 1 week ago
If you don't understand when *not to take a supplement/peptide, then you don't understand it.
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samsoete 2 weeks ago
I like this idea: One purpose in life is to build a character - a way of living and moving in this world - that you are proud of. Shaping and embodying this character becomes a main priority. Above wealth. Above fame, etc. Once you decide upon careful reflection the values and virtues you wish to bring forth in this world, then it acts as a filter/sieve for which actions and behaviours that are available to you. The rest is simply no longer of consideration. Of course, not so easy to implement, but you can practice this constantly, day in and day out. Some quotes on character by the mighty Marcus Aurelius: "It can ruin your life only if it ruins your character. Otherwise, it cannot harm you-inside or out." "Settle on the type of person you want to be and stick to it, whether alone or in company." "You fail your soul when you fail your principles." "Your task is to stand straight; not to be held straight." "I was once a fortunate man but at some point fortune abandoned me. But true good fortune is what you make for yourself. Good fortune: good character, good intentions, and good actions." image
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samsoete 2 weeks ago
One thing people don't understand is that if you are eating a large amount of macros (for bulking purposes), your micronutrient requirements scale up with that. You can't increase protein + carb intake without also increasing you magnesium, potassium, B1, zinc, B2, B3, B5, trace minerals, etc. If you are eating micronutrient dense foods this typically happens by default (maybe still not enough Mg + B1 tho), but if you are macros maxxing a la body builders, this will become a problem.
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samsoete 2 weeks ago
Too many people go through life without a single thing that excites them throughout the day. Create a mindset that gets excuted about things. Figure out what excites you. Live a life with more of that in it.
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samsoete 2 weeks ago
You can tell a lot about a persons childhood (indoor vs outdoor) based on their eye health
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samsoete 2 weeks ago
From client today 🙏: "A child is a great teacher to be present in the real world"
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samsoete 2 weeks ago
Micronutrients don’t directly signal satiety, but they enable mitochondrial energy flux and efficient fuel utilzation. What does that mean for hormonal health (which are signalling molecules at the end of the day)? Thyroid hormone signals energy availability. It is basicslly telling the body: "Operate as if fuel and oxygen availability are sufficient to sustain a higher rate of energy flux" BECAUSE THEY ARE. Because ypu are micronutrient maxxing (and mitotoxin minimizzing)
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samsoete 2 weeks ago
If SSRIs helped your mental health, optimising methylation status may give you relief without side-effects of pharmacteucials. DNA methylation silences expression of neurotransmitter transport genes resulting in increased levels of serotonin & dopamine activity. This is oversimplified, many mental health issues can stem from overmethylation as well but it is worth looking into.
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samsoete 2 weeks ago
Micronutrient maxxing is actually a lot of fun. Just know that if your digestion is compromised covering intake requirements isnt enough. Its worth looking at functional markers to check if pathways utilizing specific vitamins and minerals are working optimally. Those with chronic issues likely need significantly more than RDAs. But for health optimisation purposes, it is a great skill to cover these nutritional bases with food rather than supplements.