While light is God, polarized light is evil. If you destroy melanin at any level, you've got a problem. That's what's happened with the 49ers, it's what's happening with my osteoporosis patients, it's what's happening to the astronauts in space Brett Hanson: "If God is light, light is God, and if that is the case, then what is evil? What is the satanic pull of all these people?" Dr. Jack Kruse: "[…] That would be polarized light, light that we're not based to operate with. Let's be quite frank. If you understand the thesis that I've tried to teach people about evolution or God, you know that light is primordial. That's in the book of Genesis, but God's never told you the recipe. What did I tell you is the key to the recipe in this podcast? The leptin-melanocortin pathway. "So realize that melanin, way back 4.2 billion years ago, when the only two things alive on the planet were bacteria and archaea, even before them melanin gave you a shield. Why did you need a shield then? There was no ozone layer. Why? Because there was no oxygen on the planet. So that meant that when life began it had to begin below the surface, underneath the ground, and at hydrothermal vents. So what magically happens? Melanin comes. Why? Because the stimulus on Earth is UV radiation is pounding on it for half a billion years. So what happens? It interacts with D-shell transition elements, specifically iron, copper, manganese, molybdenum, also deuterium. And what magically happens? Melanin shows up on Earth. Where does melanin first shows up? […] "In bacteria. When the bacteria get a melanin shield, they're able to come to the surface. Then what happens when they come to the surface? Couple billion years later, you get into the great oxygenation event, you start making oxygen. What happens? What is the first step? […] Photosynthesis is how you make the entire food web. But how did life begin? "Radiosynthesis. What is radiosynthesis? Radiosynthesis is when you take melanin, you absorb all frequencies of electromagnetic spectrum, and you turn it into a DC electric current. It turns out that's the first thing that happens on Earth. "Then what else does melanin do? It actually chelates these D-shell transition atoms. All of those atoms to this very day they're still important on the inner mitochondrial membrane. Only then after almost three billion years then do you get photosynthesis. Then what reverses photosynthesis? That's mitochondrial biology, oxidative phosphorylation. So what did I just tell you? Radiosynthesis was first. […] How did we find out about it? "In 1986 Chernobyl blows up, right? Everybody heard about that. They put a concrete shield over the thing because of the gamma radiation. They tell everybody in the world, Russia, United States scientists, Chinese scientists, everybody said the same thing. Humans will not be able to go there in a thousand years. So what magically happens 25 years later? "The deer, the bear, the boar, butterflies, and flowers are all growing around Chernobyl. So what do they do? They drill a hole in the core, and they take a robot and put the robot in and see what's going on. They find inside there's bacteria that have melanin and fungi that have melanin that are absorbing the gamma rays and turning it into a DC electric current and changing the whole environment so that it's not dangerous for the animals to be in. "So guess what? We found out that life has another way. […] Radiosynthesis is how it began. That's how we took light and abiotic atoms from the periodic table in the dirty chemistry 4.6 to 4.2 billion years, and magically what's the first thing that really shows up? Melanin. That's how the story starts, my friend. "So, if you do anything to destroy melanin at any level, you got a problem. That's what's happened with the 49ers, it's what's happening my osteoporosis patients, it's what's happening to the astronauts in space. Anywhere you look, that problem's there. […] If you know how to renovate your melanin right away, you never devolve into a chronic disease that MAHA is trying to solve." Dr. Jack Kruse with Brett Hanson @ 01:35:58–01:40:58 (posted 2026-02-08)

Get as much outside or outside-like time as possible. Don't underestimate driving with the sunroof open. Don't underestimate opening windows. Block artificial light before sunrise. Block blue light after sunset. Eliminate non-native EMFs that are on the body like AirPods, Apple Watch, or cell phone Dr. Max Gulhane: "So you're seeing a patient like this: they're having problems with fertility, they're having problems with weight gain, they're not perhaps hormonally optimized. What do you like to do and guide them through in terms of helping them? And we've already talked about a little a couple of things." Carrie Bennett: "Foundational is light environment. I do lay that down as the first. So we talk about what can one do to block artificial light before sunrise to make natural light the first signal that really hits their eyes and communicates to their suprachiasmatic nucleus what's going on, and their hypothalamus. So that's step one. "And then getting as much what I call outside or outside-like time as possible in the morning. So don't underestimate opening windows, don't underestimate driving with the sunroof open, don't underestimate like you know, I have clients who take a little break, or they have they make a phone call, but they make their their work phone call in their car with their windows down, right? So like just saying, 'What can I do to get more natural light exposure in the morning?' I've got teachers who turn off their fluorescents and do they crack open windows and they stick their heads out in between classes when there's like a five minute change, and they sky gaze a little bit through the screen. Like all of these things matter, because anytime you can sync up with the correct signaling from the light your body it provides your body with information, and that's useful information the body can use to optimize its function. So that's number one. "Number two is what's happening at the end of the day. So I really think most people need a good a good pair, and it doesn't have to be an expensive pair, but a pair of orange-toned blue blockers. Because when we're filtering the light through orange we're preventing the brain from sensing blue and that signals to the pineal gland it's the night time and it can start to make melatonin. So we see optimization of hormones on that end of the spectrum plus elevation of melatonin to help with all the repair. "And then in conjunction with that, Max, is like a lot of things these are people who probably have a lot of mitochondrial dysfunction. So I say we because I co-teach a fertility course with Sarah Kleiner, and so we really talk about things like what can we do to support mitochondrial health and that would be, What does red light therapy look like? What is cold exposures and cold plunges look like? What about deuterium? Are these people who have to do things to help support deuterium levels in their body? So there's talk around other things as well. "And then lastly we really are diligent about helping people slowly eliminate their exposures to non-native EMFs, because oftentimes it has to be a gradual process. We start first with the non-native EMFs that are on someone's body. So this is someone who was typically wearing AirPods all the time, or an Apple Watch, or had a cell phone in their pocket, or on their purse all day long. We start to remove those exposures. Then the next step is can you hardwire your workstation you know can you turn off your Wi-Fi at night can you put your phone on airplane mode whenever possible little things like that can start to make a big difference in what the mitochondria perceive as a threat, so that they can optimize their function during the day as well." Carrie Bennett with @MaxGulhaneMD @ 34:30–37:37 (posted 2023-05-28)

Having breakfast shortly after sunrise signals to your body that food is plentiful. When you sync up all your circadian signaling & leptin signaling it shuts off hunger signaling later in the day. This can be a powerful tool for weight loss Carrie Bennett: "I'm not against intermittent fasting. It just has to be done in the complete exact opposite [of having coffee on an empty stomach in the morning and not eating until two o'clock in the afternoon]. It has to be an early fueling window, so from sunrise when you have breakfast till six to eight hours later, you've signaled to your body food is plentiful. Then […] it can go into a kind of repair mode. It doesn't need anything else for the day. So if someone wants to intermittent fast, I'm not against it. It just has to be done in that early fueling window, because of the fact that otherwise it's going to signal a stress response in the body." Dr. Max Gulhane: "Yes, yes. And I've had some great success with some of my patients who are interested in doing a bit of fasting and doing time-restricted eating in conjunction with something like a carnivore diet. They ate from 07:30 AM after the sunrise to about 11:00, and then no more, an incredibly powerful tool for weight loss." Carrie Bennett: "And you know it works with leptin too, because people when they do that they actually have low hunger in the evening. The biggest complaint with a lot of the clients I see is, 'Well, I can't do that because I'm going to be starving at night,' and it's the exact opposite. When you've synced up all of your circadian signaling and leptin signaling is strong it says, 'Carrie's got enough body fat on her body. She doesn't have to worry about finding, hunting, gathering more food,' so it really shuts off hunger signaling later on in the day." Carrie Bennett with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 21:35–22:53 (posted 2023-05-28)

Early morning coffee on an empty stomach will artificially elevate cortisol. Delaying the first meal until afternoon will push cortisol to stay elevated. Elevated cortisol will elevate blood sugar, which may raise insulin and compete with leptin signalling Dr. Max Gulhane: "I love it that you mentioned that we should be eating close to seeing this morning sunrise, getting that circadian program early in the day, and then eating soon after to signal abundance. Another facet of this profoundly disordered modern daily routine that I encounter is people will drink a strong coffee, double coffee, […] and then they won't eat until 10:00 ᴀᴍ, 11:00 ᴀᴍ, midday. […] Another point you made was that you do get an appropriate morning cortisol rise. How do you think about cortisol, which for the listeners is a one of the hormones that is involved in the stress response, how do you think about that early morning coffee on an empty stomach, and that lack of nourishing food as it relates to cortisol?" Carrie Bennett: "It's going to artificially elevate cortisol. […] If you have that coffee before sunrise you get a surge of cortisol without the circadian signaling, and so that can dysregulate things even more. And you're right, clinically I do, because coffee can be an appetite suppressant, so it's very easy to see people who want to do the best for their health by intermittent fasting, but they will push off and push off and push off their first meal until about two o'clock in the afternoon, and then they'll maybe eat from 02:00 to 06:00 or 02:00 to 08:00, somewhere in there. But in the meantime, what they've done is they've really dysregulated cortisol and pushed cortisol to stay elevated, because cortisol helps to regulate blood sugar. Cortisol can help the body to make new blood sugar when we're not giving the body any fuel. "And so one of the things that I see is exactly the pattern you've presented, and it's this idea that it's almost easy to delay, delay, delay, but it's even more dysregulating of hormones (including leptin), because when cortisol has to stay elevated to elevate blood sugar, you oftentimes see kicks up of insulin, and that again can dysregulate or compete with the leptin signaling in the brain." Carrie Bennett with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 18:03–20:17 (posted 2023-05-28)

"I tell people if they can front-load their light exposure in the morning it's going to be a benefit. The light that they get before solar noon, from my clinical experience, is way more important than the light they get from noon till the end of the day. And then at the end of the day it's about blocking the artificial light, because that can kick start hormone imbalance as well." — Carrie Bennett, with @MaxGulhaneMD @ 17:42–18:02 (posted 2023-05-28)

Seeing the sunrise tells mitochondria in adrenal glands to make pregnenolone. Having breakfast really close to sunrise signals that food is plentiful. Most importantly, seeing the UVA rise in the morning optimizes other pathways in the brain Carrie Bennett: "There's some key signaling that happens in that hypothalamus involving what I call like this sequential layering on of the light in the morning that optimizes not just leptin signaling in the brain, but also a lot of other pathways controlled by the hypothalamus that do support fertility and just overall health. "So first and foremost, I don't think people realize this, but when we stare at an artificial screen, that amount of blue light is pretty shocking to the brain. It sends a confusing circadian signal, unlike if we were just living outside, right? At sunrise […] when the sun reaches the horizon you see a balanced amount of red and infrared light and blue. And it's like this balanced amount of red and infrared and blue, it actually kicks off signaling in the hypothalamus to communicate to the mitochondria in the adrenal glands to make pregnenolone, which can then be converted into cortisol. So that's a key signal, right, because pregnenolone is the start of a steroid hormone pathway which involves all the sex hormones. "So step number one is we have to signal to the mitochondria that the day has started, and so then that pregnenolone production gets optimized. And when pregnenolone gets optimized, another thing happens. The mitochondria have to kind of take a snapshot based on if leptin was able to communicate in the brain last night, what at the night before when we slept. The mitochondria have to say, 'OK, how much of this pregnenolone do we need to divert to cortisol, which we want us at a circadian appropriate surge in the morning, but we don't want it to be too high, we don't want it to be too low. And then the rest of the pregnenolone can get ferried off into the other rest of the steroid pathway to balance things like the estrogen, progesterone, DHEA, testosterone.' So step number one is we got to really consistently kick that pathway off, and when we don't have the right circadian timing going on with that, that could be very chaotic to mitochondrial function in general, but especially hormone balance. "And then I always say that in order for the mitochondria to feel safe for them to say, 'OK yes, we are capable of conceiving and growing a baby,' would be they need to know the time of day, so we went outside and we just did that, right? We got them the circadian signal. "They also have to know that the food is plentiful. So they did that with leptin signaling the night before, and then they'll do that if we also have breakfast really close to sunrise, because that breakfast then will also signal, 'OK, food is available in Carrie's environment.' So we know the time of day, we can divvy up the steroid hormones appropriately, and yes, Carrie has enough food in her environment, she's not going through a period of food scarcity. And if we do those two things pretty consistently the body starts to get in this rhythm that all is copacetic. "And then you add on what I call UVA rise, which clinically, Max, I have found to be one of the most important times of the day in general to optimize light outside, because as soon as UV light appears in one's environment, it optimizes other pathways in the brain. […] "If we can optimize some light exposure outside in the morning it can do wonders for so many things including hormone balance and fertility." Carrie Bennett with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 12:43–16:00 & 17:10–17:19 (posted 2023-05-28)

Weight struggles, irregular periods. Leptin signals how much energetic reserve you have. Snacking all day will hamper leptin signaling. Craving carbs every two to three hours. Cortisol elevation due to screens & artificial light at night disrupts circadian signaling of leptin Dr. Max Gulhane: "I see a lot of patients who are having weight struggles, that their weight isn't moving. They're perhaps having some irregular periods, and they're doing a lot right in terms of diet. So can you talk to us about this hormone leptin and how does that relate to hard to shift weight, and how does that relate to the light environment?" Carrie Bennett: "Sure, absolutely. I'll talk about leptin first. Leptin is a hormone that gets released from our fat cells and docks to a key part in our brain called our hypothalamus. I want people to think of the hypothalamus as like a major control hub. It's where you also have our suprachiasmatic nucleus which is our circadian clock in our brain, the main clock in our bodies that's telling time. The hypothalamus has connections to things like the thyroid, the gonads, the ovaries, to the adrenal glands. So signals that go into the hypothalamus are very, very key. "One of the things that leptin does when it signals into the hypothalamus is what's called energy homeostasis. Basically, it downloads, 'OK, Carrie has this much body fat on her body, and this much stored energy and reserve.' And from that snapshot in my brain, my brain gets to decide, 'Does Carrie have enough body fat to be fertile and sustain a pregnancy? […] Let's regulate Carrie's appetite based on that.' What oftentimes happen is we don't get some key, that leptin doesn't get the opportunity to dock in the hypothalamus appropriately, for two reasons that I see in clinical practice. "Number one, insulin competes for leptin for the same receptor site in the brain. So if insulin is elevated, which we see happening with people who kind of snack all day long even if it's clean snacking, if they're snacking all day long there's usually some competitive inhibition happening in the brain for leptin to dock. "And then the other time that leptin really docks and does a download is at night when we're sleeping. That can get disrupted by things like cortisol elevation at night due to us seeing screens and artificial light at night. That can get disrupted because we're not going to bed in time to get a really good circadian signaling of leptin happening. "And so if leptin can't do its job and download and say, 'This is how much energetic reserve Carrie has,' the main thing that's going to happen is it's just going to make the assumption that, 'Carrie is starving.' And so what is it going to do? It's going to basically prevent body fat from easily being metabolized, and it's going to signal that I'm hungry, and it's going to signal that I'm hungry for carbohydrates because that's a very easy fuel source for the body to break down and derive energy from. "So that's a typical client profile I see, someone who is weight loss resistant, has weight to lose, and also has these cravings for carbohydrates every two to three hours. And it just creates this effect of the body doesn't know how much energetic reserve it has to be able to liberate the weight and to say, 'Oh yeah, Carrie does have enough weight either to have a baby or actually to lose some of that body fat, because it's not beneficial for her to be carrying that much adipose tissue on her frame.'" Carrie Bennett with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 08:19–11:41 (posted 2023-05-28)

Long-term plantar fasciitis inflammation issues may be due to circadian disruptions impacting the collagen synthesis to create a different type of collagen that's thicker but not as stretchy Peter Cowan: "Yeah, I do think it's really important to emphasize the circadian stuff because this is something that is completely mainstream now. If you go to PubMed and you look up circadian disruption, basically any issue, you're going to find dozens of papers. Specifically for this collagen synthesis one, though, there's some really good literature on it, and I dug through it. It's not actually that hard to understand. You don't have to know the quantum mechanics or the biophysics even. There's an enzyme called lysyl oxidase that's on a circadian timing mechanism, and then I mentioned MPP earlier […]" Dr. Max Gulhane: "Is that matrix metalloproteinase?" Peter Cowan: "Yeah, exactly. […] The fibroblasts are also on a circadian mechanism so you're getting the effects of basically downgrading of the mitochondrial function in those fibroblasts are very mitochondria dense. But then on the other side you're disrupting the timing, so it's kind of like a double whammy. Then you got the lysyl oxidase factor which is critical in giving that kind of cross-linking that is required for the collagen to become just like the sturdy, stretchy, rope-like, cable-like material. When it's not cross-linked, and the fibroblasts are producing incorrectly, you get a different type of collagen that's thicker but not as stretchy, so it's more prone to breaking when under high loads." Dr. Max Gulhane: "Yeah. So it's compromised. The body is making a tradeoff in the production of these factors to do the best under adverse conditions. And yeah, that sounds plausible to me." Peter Cowan: "I there was an ex-49ers who tweeted. He's like, just for what it's worth I never had plantar fasciitis in my life except for when I was in the 49ers. And plantar fasciitis, you probably can explain, there's like an acute one and a long-term one, there probably is a different technical term, but basically long-term plantar inflammation issues is characterized by a switch I think from collagen type three to type one, or whichever direction. And it's documented in the literature; it's not controversial at all." Peter Cowan with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 52:50–55:29 (posted 2026-01-27)

In plantar fasciitis the arch of the foot is usually very tender to palpation and seems quite clearly to be a manifestation of Tension Myositis Syndrome "The pain in _plantar fasciitis_ is located on the bottom of the foot along the length of the arch. Although they are often vague about cause, doctors may ascribe this pain to inflammation. The area is usually very tender to palpation and seems quite clearly to be a manifestation of TMS [Tension Myositis Syndrome]." John E. Sarno, M.D. (1991). _Healing Back Pain: The Mind-Body Connection_, Hachette Book Group, New York, NY, p.117

Dr. Jack Kruse: "I would also ban sunscreen and sunglasses the first day I came in because this is one of the biggest problems. People don't understand. When they hear this, they go, 'But Jack, you're decentralized. You said everything should be available.' Like, I'm okay with it being available; I just don't want you to buy it. Like, I want girls to put the sunglasses on the top of their head or in between their boobs. It looks great there in the pictures. Just don't put it on your eye. You know, if you want sunglasses, sell the [blue-blocking] glasses that you have on your face. That I'm OK with." Max DeMarco: "Yeah. How bad are sunglasses? How much do they disrupt your circadian rhythm and like this clock in the eye?" Dr. Jack Kruse: "I'll make it very simple. Sunglasses are an oncologist's best friend. It's a growth machine for oncology practice. How's that?" Max DeMarco: "So sunglasses slowly kill you?" Dr. Jack Kruse: "Well, sometimes not slowly at all. Sometimes pretty quick, especially if you took the jab." Dr. Jack Kruse with Max DeMarco @ 50:09–51:00 (posted 2025-05-07)

Circadian disruptions are likely to be the biggest contributor overall to the injuries seen across professional football Dr. Max Gulhane: "But if we take a step back and think a bit more about the environment that the players are in. Sure, we're implying or suggesting that being in this [49ers] facility and being exposed to this magnetic field is not ideal, but like what else is happening in the modern athletes' environment that could potentially be impacting healing?" Peter Cowan: "Yeah, I'm glad you asked that because I actually think that circadian disruption is a bigger factor overall. I think that the EMF from the substation is likely kind of like the straw that broke the camel's back for the 49ers, because you're seeing these soft tissue injuries across the league, across all professional sports. […] "But I would just encourage anyone to look at the third article of my series. It's non-controversial circadian mechanisms showing exactly how collagen synthesis and repair is based on timing mechanisms, based on our light exposure. And these football players, when they're not playing games, they're working out indoors under artificial light, and they're staying up watching film reels, analyzing plays when it's dark out. And then they're traveling across multiple time zones every week, practically every week. Then they're playing these games outside with this massive bright lights on them. So that's the circadian stuff. "You can actually see that a lot of players are now starting to use blue blockers, and I've heard that some teams even have like a wind down twilight protocol. I haven't seen actual documented evidence of it but I wouldn't be surprised. This stuff is not really that cutting edge anymore. It's becoming very mainstream. So I think that alone is enough to be causing these issues." Peter Cowan with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 45:01–47:10 (posted 2026-01-27)

I don't enjoy cold exposure. Why is that? People with more uncoupled haplotypes tend to benefit more from cold exposure & are more likely to enjoy it. People with more tightly-coupled haplotypes tend to benefit less from cold exposure & are less likely to enjoy it Archie: "I've been resistant to consistent full body sort of cold exposure. I haven't taken to the trend. […] I might sort of finish off lower half of the body with a cold shower occasionally. It does feel refreshing but […] I do my best to avoid that. […] What is the benefit of doing the equivalent of a cold plunge or finishing off with a proper cold shower?" Dr. Jack Kruse: "[…] It's a default reset. […] There's something in physics called the Curie point. It has to do with magnets. OK? When you drop temperature down magnets become more efficient. What else becomes more efficient in terms of electricity? Semiconductors work better in cold. So, if we took your phone and we put it on the hood of the Mercedes-Benz out in the front that's black, you get a temperature warning. We come in here and put it inside the freezer, it will work right away. "Well, I told you that we use semiconductive current in us. So, the benefit of you going in cold water, even if it's a short period of time or a longer period of time, you become more thermally efficient. In other words, you set your electronic state for the proteins in you and the water that surrounds them, because the water that surrounds you is also a semiconductor. In other words, you become much more likely to conduct a semiconductive current which means that you do better. So that's the main reason that you want to do it. "Now I will tell you in different people the effect is different. I'm going to tell you all mammals it's beneficial, but humans are a special case, and I'll explain to you how we found this out. If you have an uncoupled mitochondrial haplotype, which you're kind of close because you're originally from Turkey, Middle East. So, you're probably not as uncoupled as I am. My people are from the 59th latitude. So, I'm very uncoupled. So, when I go in cold water, I get a huge benefit. My mitochondria not only make more water, they release more red light, but they also make a ton of water. That light actually allows me to tan the insides of my body. So, I'm turning on the system that controls melanin inside of me. That's another benefit. "Now, people who are from equatorial Africa who have L0, 1, 2, and 3, these are predominantly people have dark skin. In country you're living in now, those are the bush people. OK? But in Africa, like Nairobi, one degree north, 8,000 ft up, these are the guys that beat everybody in the world in endurance sports. Why? Because they are extremely thermally efficient. But the interesting thing is they don't get the huge benefit out of the cold. How did we find that out? In the Korean War in the United States, when they put people up on the peninsula, you know that North Korea is pretty high latitude. It gets pretty cold. The US military found that black soldiers got frostbite faster than white soldiers, and they couldn't figure out the reason why. It's because they're not thermally able to handle because the amount of melanin that they have on their exteriors. […] "Now, what's the beautiful part of this? People that tend to be heavily melanated tend to be always either at altitude, where there's EMF, or where it's warm. Very rarely are they heavily melanated. There's exceptions; those exceptions are like the original Eskimo." Dr. Jack Kruse with Archie @ 42:08–45:29 & 46:36–46:55 (posted 2026-02-03)

All vaccines are useless as they're based on faulty science. Kids have food allergies & peanut allergies now because we've been vaccinating like crazy this whole time. Anytime we inject a young child with anything, they become hypersensitive to that issue Max DeMarco: "Regarding vaccines in general, […] can you say all vaccines are bad, per se, or is there. . ." Dr. Jack Kruse: "I can, but nobody else wants to hear it. But I think they're all useless. I think they're based on faulty science, and that's the reason they have no controls. It's all by design. And I think centralized doctors, the biggest lie is not statins, it's not cholesterol, it's actually vaccines. I personally think they're all useless. And I didn't have that belief my whole life. I used to believe in the camp that vaccines were wonder drug like penicillin was from Alexander Fleming. But then over my career, I started to notice some very interesting things, and then I went back and looked at the papers. "Like for example, when Andy Wakefield got canceled by the British centralized doctors, I thought it was interesting what he was saying that the MMR vaccine had a lot of problems. So I decided to look into the MMR vaccine. […] The first thing I did is I went back and looked at the tables of when the MMR vaccine, and what the incidence of measles was, and when vaccination came in. The vaccination program came in after measles was already rare. So why the hell did we make a vaccine for a disease that wasn't a problem? "Same thing was true in polio. And the polio idea is what really opened my mind to this because I learned about that when I was a young resident. […] When I realized that there was a big farce behind polio, that not only was some of the people who we were taught in our history books had polio, I'll give you an example. Franklin Delano Roosevelt, FDR, many people sold the idea that he had polio. I'm not convinced that he had polio anymore. I think he may have an autoimmune condition called Guillain-Barré syndrome, for a variety of different reasons. And do I think polio as it was sold through the March of Dimes, FDR, and the industrial military complex through Salk, did we really need a polio vaccine? No. I think the government needed this program, and big pharma needed the program. […] "And then if they look at some of the Nobel prizes that were given for the early vaccination idea, this was done by a French physician where we got the word anaphylaxis. What did actually he show? Anytime we inject a young child with anything, they become hypersensitive to this issue. That's actually where most of the side effects for vaccines come from. Why? because you're fine-tuning the immune system to react against this. "So when pediatricians ask me, 'Why do all these kids have food allergies and peanut allergies now?' It's because we've been vaccinating like crazy this whole time. It goes back to that original Nobel Prize that nobody wants to talk about. Why? Because how you get taught this in medical school is actually built on a curriculum that big pharma pays for and gives to the medical school for free. Where did that idea come from? Rockefeller and the Flexner report." Dr. Jack Kruse with Max DeMarco @ 51:01–53:13 & 54:13–55:04 (posted 2025-05-07)

Dr. Niels Ryberg Finsen won the Nobel Prize in 1901 for the use of UV light in treating tuberculosis pemphigus vulgaris. To this very day, when you have drug-resistant TB, the single best thing that still works is sunlight with UV light Dr. Jack Kruse: "People forget this. Finsen won the Nobel Prize in 1901 for the use of UV light in treating tuberculosis pemphigus vulgaris. This is a bad infectious disease. Do you know to this very day that when you have drug-resistant TB, the single best thing that still works is sunlight with UV light? Even today. But people when I talk to doctors, they don't even know that UV light was given a Nobel Prize before any drug was. It's shocking, you know, when I say this stuff to people because like a young man like you have grown up in a world where, 'Oh no, no, no, penicillin, this and that, these are the greatest things ever.' "And then I casually point out to people, well, everybody seems to know about this polio thing, but they don't know why Jonas Salk and Albert Sabin didn't get a Nobel Prize for that. Why? Because it harmed a lot of people because it was tainted with SV40. OK? And that's the interesting thing. "Everybody knows about Alexander Fleming and penicillin, but penicillin hardly works for anything at all. Why? Because we overuse it and abuse it because we don't understand the decentralized nature of man, and that is the key. And this is the reason why we have so many different things wrong because once the paradigm was stolen from us to centralize medications and centralize our ideas all the things that are found in nature were lost." Dr. Jack Kruse with Max DeMarco @ 58:58–01:00:23 (posted 2025-05-07)

Optimizing the three master hormones (leptin, cortisol & melatonin) affects downstream hormones like estrogen, progesterone & testosterone. Leptin resistance & insulin resistance. Leptin resistance & PCOS. Leptin resistance & infertility. Leptin resistance & hot flashes Sarah Kleiner: "Leptin resistance is a precursor to insulin resistance. It happens first, and that's where a lot of people come to me they're like, 'I've gone through the testing, I'm not insulin resistant, my blood glucose is not diabetic or even pre-diabetic yet, but I'm having all these symptoms.' And the literature is quite extensive around leptin at this point because like I said, it's been discovered in 1994, but there is a tie with leptin resistance and PCOS, leptin resistance and unexplained infertility, leptin resistance and hot flashes. A host of hormone imbalances, which people are usually having these hormone imbalances first, and everyone's like, 'Oh, it's estrogen. Oh, it's progesterone. Oh, it's testosterone.' I'm like, 'Yes, but you don't understand those are downstream hormones.' Right? "We've got leptin, cortisol, melatonin. These are up at the top, and then everything else is underneath, and thyroid as well. If we can optimize leptin, cortisol, melatonin, these three master hormones first, a lot of times these issues with these hormone imbalances, regardless of what it is, they work out. And I think that can be hard for people because they're in this mindset of, 'I have to do this extensive testing. I have to spend all this money to find out if this hormone is low and this hormone is high, or this hormone is you know,' and they get all tied up in these numbers. "When I like to just, it's a lot more simple, and it's a lot cheaper of a route to take to address things in this kind of top-down manner, because again like you said, leptin resistance is a precursor to insulin resistance. There's a ton of literature around insulin resistance as well, especially in regards to hormone imbalances. If these things are not optimized then supplementing exogenous hormones, trying to do specific strategies to raise specific hormones and lower other hormones, it's just kind of like you're chasing your tail, and it could be a big waste of time. "And I know that because that's what I was doing kind of on my fertility journey. It was like, 'Oh, your your DHEA is low, your testosterone is low, this is low, estrogen is a little bit high.' So it's like, 'Let's take this supplement to bring this up, and push this one down,' and like I said, I only would get so far. It would help a little bit, but then I still wasn't getting pregnant, and the weight wasn't coming off. It was just like this big cycle of spending money, and yeah, it was a big waste. Very frustrating." Sarah Kleiner with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 20:08–22:58 (posted 2023-10-15)

Struggling with infertility and stubborn weight loss resistance. Discovering leptin, the master circadian signaling hormone. Discovering that circadian practice is absolutely crucial to this whole process. It seemed too simple to be true Dr. Max Gulhane: "In my general practice two of the most common presentations that I see in in my female patients are fertility optimization and just stubborn weight loss resistance. And what […] I really love is how […] you eventually got to the root cause of how to optimize your fertility, and optimizing your fertility was as a side effect of optimizing your biology. […] And I think it's an amazing testament to do a practice that […] you were able to fall pregnant at the age of 42 […] completely naturally. […] So explain from your point of view what this leptin-focused strategy involves. How is that different and more nuanced than simply the diet, or the low carb, or the carnivore-based kind of approach?" Sarah Kleiner: "Yeah, absolutely. I also failed to mention that I lost 30 lbs before I got pregnant. I had talked about that stubborn 20 lbs that I had picked up seemingly out of nowhere. When I implemented these principles I lost 30 pounds and then got pregnant. I don't want people hyperfocused on losing weight if they're trying to optimize fertility, because you don't want to be underweight. You do want […] to be at a healthy weight to be fertile, it's important, so I don't want people to get hyperfocused on that. But I do love to mention that fact that I didn't track, I didn't overexercise, I didn't go crazy with the weight stuff, and it just kind of I lost the weight as a side effect of implementing these things. "But essentially, leptin, it's important, […] it's a master circadian signaling hormone. It impacts your thyroid, it impacts insulin, it impacts your sex hormones. […] Again, it's a master hormone, so it signals all these downstream hormones and impacts them. It even impacts your immune system and bone health, heart health. I mean there so many things that we continue to learn about leptin. It wasn't even discovered until 1994 so there's a lot that we're still learning. "But essentially we want really strong circadian rhythms, and that's one of those things that I always thought was just silly, it's like too simple to be true to go out and look at sunrise every day, and to wear blue blockers after dark. A lot of people dismiss those things, and just want to focus on the food. And then they focus, focus, focus on food, and nothing. They get a little bit, they get a little result, but then they still have lingering issues, maybe thyroid, weight, […] it's still like some of it's coming off, but the rest of it just really isn't. "And so that circadian practice is absolutely crucial to this whole process, so I'm like it you have to do that first. And that involves sunrise, and then the next window is UVA. And people are like, 'How long can I spend out? What's the minimum amount of time?' And I'm like, 'You're looking at it all wrong. I get it. I know people are busy, they have busy lives. But if you go into this thinking like, What's the minimum I can do?' Yeah, I can help you if you have a busy life, and a schedule and all that, but I just I hate when people kind of look at it like, 'What's the minimum I can do?' "I make it a game. What's the maximum you can do? How can you shift your life and shift it? If you really want to heal, you're going to have to shift, and you're going to have to change, and it's a mindset that you're going to have to go into, to like, 'How long can I spend outside in the morning?' And so I think that's really, really crucial for people." Dr. Max Gulhane: "Yeah, and the way I think about circadian biology having come from a predominantly dietary-focused paradigm is coming to an understanding that this is basically the master regulation of our biology. It's like if you don't respect circadian biology you're going to get wrecked. You're going to have a bad time." Sarah Kleiner with Dr. Max Gulhane @ 11:14–16:10 (posted 2023-10-15)

To the ladies in the South with osteoporosis: when you're out having coffee in the morning, take your shoes off, sit on the porch and make like the Sphinx. Look to the east and keep all four of your extremities grounded. Avoid fluoridated water when making your coffee Dr. Jack Kruse: "When you understand how to use purple and red light, that's when your life changes. That's when my life changed. And you know, the really cool thing from my perspective is when you invite me on to do a podcast like this, we jump down the rabbit hole, and we can discuss all the quantum effects and the detailed science. But here's the best part. How hard is it for a patient? It's not hard at all. You know why? "All I do with my ladies in the South that come to me with osteoporosis. So when you're out having your coffee in the morning, I just want you to take your shoes off, sit on the porch and make like the Sphinx. Look to the east and keep all four of your extremities grounded. And they look at me like, 'That's it?' I say, 'Yeah, if you don't mind, when you make your coffee, make sure it's not done with fluoridated water.' "Now, very few of them ask me why, but the ones that do, usually they've been a patient for a while. I tell them why, because what does fluoride fundamentally do to water? It decreases the amount of DC electric current that you make from sunlight. Why? Because fluoride is a dielectric blocker in water. See everything always scales to the same three things, Dan: light, water and magnetism. And that's what a mitochondriac spends most of their time studying." Dr. Jack Kruse with Dr. Dan Pompa and Meredith Dykstra @ 49:06–50:27 (posted 2017-01-13)

See the sunrise in order to renovate heme proteins and to control the efficiency of the Krebs cycle & the urea cycle. Kids with autism tend to love carbs because they can't use the TCA cycle or the urea cycle well. Help them by getting them outside to see the sunrise Dr. Stanton Hom: "Could you share with our audience what you are finding as the most viable ways to generationally help our families experience greater potential?" Dr. Jack Kruse: "[…] Are there basic things that I think everybody can do? Yeah, the number one thing hasn't changed for me in 20 years, you must see the sunrise. And the reason you must see the sunrise is twofold. You have to renovate the heme proteins in your mitochondrial membrane. The heme protein that most people may not know, it's called CCO or cytochrome c oxidase. That makes a special kind of water, not the water comes out of your tap. It's called deuterium-depleted water. Deuterium-depleted water is important for one reason. It actually controls the optical density of light inside of you. So guess what? That's a big deal. What's the other thing that it controls? "It controls the stoichiometry, and I'll explain to you what that word means, the thermodynamic efficiency of the Krebs cycle and the urea cycle. These are the two big cycles that control all these little boxcars that you learn about in biochemistry. Each one of those boxcars has an absorption and emission spectra; that means that light is involved with each step. "So for example, you've probably heard of people talk about ketone bodies and β-hydroxybutyrate. When you talk to Uncle Jack, when you say that, I'm immediately thinking about the light frequencies that those things carry. I just did a podcast with Sabine Hazan who is gastroenterologist is big into the microbiome. And when I talked to her and Alexis Cowan, who's a PhD in biochemistry, I explained to them the same thing is true in the microbiome. What do we know like in autism? Kids in autism have had bifidobacteria completely eliminated. It's almost been an extinction event. So what is the case there? "That tells us that a certain amount of light is not present in these kids with autism. And the process that they went through to get the disease causes this problem in their microbiome. Dysbiosis in autism is not what I would call something that's really well talked about in most areas. But most parents that have kids that are significantly autistic, the one thing they know, those kids tend to love carbohydrates and sweets, and they tend not to like ketones […] or fats. The reason why is because they can't use the TCA cycle or the urea cycle well, because their mitochondria are damaged. And the parents are not being told that they need to take the fucking kids, wake them up, bring them to the sunrise. I don't care if they're screaming and crying, they go nuts. You need to use that because that effectively fixes the big problem, and then we move on from there. "And once you get people on that right path, you get them in that groove, you begin to realize that all the boxcars that are in biochemistry and the urea cycle and TCA cycle, these are all lightsabers that actually get your kid better. And that's really the way I want you to think about it. I don't want to reteach you biochemistry. I don't want to teach you quantum physics, but I'm going to tell you at the base of health and disease is light, water, and magnetism." Dr. Jack Kruse with Dr. Stanton Hom @ 55:58–59:26 (posted 2025-08-01)

259: Decentralized Health: Dr. Jack Kruse on Light, Water, and Freedom – thefuturegen

Heteroplasmy: a measure of mitochondrial inefficiency. If you reduce heteroplasmy, say from 70% to 30%, a disease like diabetes can vanish. Melatonin made by mitochondria gets energized by purple & red light found in AM sun to perform autophagy & apoptosis renovation at night Dr. Jack Kruse: "And when that energy efficiency [of the engine] goes bad, that is heteroplasmy. So in us, what is our engine? The mitochondria. When the energy inefficiency of the mitochondria begins to go up, we have problems. "Now the interesting part that [Doug] Wallace first dug out from his work is that he found that every decade we age, heteroplasmy goes up about 10%. So we now know that aging is tied to a loss of thermodynamic coupling in mitochondria. And then he later figured out in the 1990s and 2000s that as you got a disease like neurodegeneration, or autism, or Leber's optic hereditary neuritis, that the heteroplasmy rate can go up in short periods of time and then the disease manifests. "And then the flip side of that also shows that if you can knock the heteroplasmy, say from 70% to 30%, a disease like diabetes can vanish. And this broke everybody's paradigm. […] Why is it good for people with injury? Because it explains to you that you don't have to take your Ferrari to a mechanic. Your [mechanic] in you is the two change programs called autophagy and apoptosis. Those are what takes out the bad engines. So you have a mechanic inside of you, and it turns out that mechanic works on purple and red light. And what are some of the things that do this? Dopamine, melatonin, GABA. These are things that I think people have heard about, probably but in different contexts than this. And out of those three, the one that's the most important, it appears (based on the latest research we have) is melatonin. Why? "Mitochondria is where most of your melatonin is made. Now, you're going to hear many other doctors come out and tell you it's from the pineal gland. […] We now know that that is […] nonsense. 95% of your melatonin is made in your mitochondria. And when you understand that it controls the two change programs, then it begins to make some sense. Because then you realize, well, this is the mechanic. "And then when you find out a little bit more about melatonin, most people think it's the hormone of darkness when it turns out it's made from an aromatic amino acid that absorbs UV light. You go, wait a minute. UV light's not present at night. So how does this work? […] You look at the aromatic amino acids that melatonin is made out of, and you see the absorption spectra, and it goes between 200 and 400 nm light. So it's clear that you're supposed to be in AM light. And these chemicals, the benzene rings in these aromatic amino acids that make up melatonin, namely tryptophan, they get powered up, meaning they get electronically excited by sunlight. That energy is kept in the benzene rings and in the π electron clouds that are in the chemical structures. […] At night when the stimulus of the light goes away, that changes the electric and magnetic fields. […] "When you change the optical density of something, you change the refractive index of a tissue. It turns out melatonin does that. So when it's dark, the light that's stored on those electrons gets released to the tissues, and that's when physiologic work can be done. That's actually when the renovation is happening to your colony of mitochondrial DNA. That's really how it fundamentally goes. And then when you understand the way that light enters us, the two primary ways are through your eyes and your skin." Dr. Jack Kruse with Dr. Stanton Hom @ 13:38–18:11 (posted 2025-08-01)

259: Decentralized Health: Dr. Jack Kruse on Light, Water, and Freedom – thefuturegen

How cold thermogenesis (CT) improves mitochondrial functioning. CT brings the respiratory proteins closer together. The closer the respiratory proteins are together the better the quantum tunneling is Matt Maruca: "When it comes to the CT series and the CT benefit that humans (and essentially all mammals) can get, does that initially descend from the extinction event?" Dr. Jack Kruse: "No, it starts immediately 3.8 billion years ago about the story I told you about redox chemistry. It turns out redox chemistry always works better when it's cooler. […] Remember what I told you that's in Nick Lane's book, that the closer the respiratory proteins are together the better the quantum tunneling is. And when the angstrom is split apart, it's a logarithmic effect; it's not a linear effect. So you lose energy production tremendously. So what does cold thermogenesis functionally do to the respiratory proteins, which is cytochrome I, II, III, IV, and the ATPase? It brings them closer together. You want that that whole complex from I through V to be within 48 to 60 angstroms. We know that from new science that's been done by people who are mitochondriacs. It turns out when you have diseases and heteroplasmy is higher they're spread out, and that's exactly what the stimulus is for apoptosis. Most people know that apoptosis is controlled by cytochrome IV. What happens is there's a whole sequence. . ." Matt Maruca: "I don't think most people actually know that [laughs]." Dr. Jack Kruse: "Well I mean they should, because what happens is the mitochondria swells, and the swelling opens up mitochondrial pores. One of those chemicals that people probably have heard is cardiolipin, and what does that do? It basically takes apart cytochrome c oxidase, and it leads to a cascade of events that's called apoptosis. Now it doesn't go fully, it can lead to fission, it can lead to fusion, there's a lot of different things that it can lead to. But that's functionally how it happens. "But it tells you again we're back to quantum thermodynamics. Most people don't realize that the tunneling of electrons requires a precise distance between the two. I've taught people ad nauseam, Matt, you remember how many times that I show you the chemical structure of chlorophyll and hemoglobin when you look at them they're identical. The atomic spacing is identical the only difference is that there's magnesium in the center of chlorophyll, and there's iron in the center of your red blood cell hemoglobin. And why is that a big difference? Magnesium is atomic number 12, iron is atomic number 26. What does that mean? You got 14 more electrons. What does that mean? You get more light, so you can be more complex. "Now you're back to the light diet again. That's how this works. Everything about you is light, and you know what? We got to get people to understand it is about light." Dr. Jack Kruse with Matt Maruca @ 45:59–49:04 (posted 2020-12-16)