Of course, there's about 10^23 molecules in a litre of water; 10^5 particles may not represent very much. A litre of water probably contains a few orders of magnitude more of radioactive particles.
The plastic may be insignificant.
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yeah it comes down to just how toxic they can be. maybe they just bounce around and get flushed out eventually, or stay around and disrupt things? biology is absolutely insane once you start going down that rabbit hole. So much systems complexity. Hard to wrap the mind around it all.
It'll depend on the type or plastic too. There are huge differences in chemistry between them.