Here is a simple suggestion for bot immunity - may be it is an opt in at user level .. - Only those who I follow shoud be able to comment or react on my notes .. In a way "follow someone" is a proactive permission to "someone" to react to my notes - reply , quote , fork or like etc .. Rest everyone can read .. - If someone want to react to my messages - they should first follow me .. and then I can choose to follow back .. - If you dont "opt in " then every time someone follows you , you auto follow back .. I know it is probably a protocol level change and it will reduce the traction (particularly for new users) .. but in the long it will help #nostr ..

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Thats why I said it is a protocol level change .. I am sure relays will find easyier way to filter the spam attacks .. but changing the meaning of "follow" would go a long way ..
When I see notifications in #Amethyst , the global view is riddled with "reply guy" ... but " All Follows" view is good ... Maybe you wanna implement same logic in feed too .. no display (and reportinng ) from anyone who I dont follow ..