a common refrain of preprint papers is that they "haven't undergone peer review"

medRxiv

Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season: A Prospective Cohort Study

Background The purpose of this study was to evaluate the effectiveness of the influenza vaccine during the 2024-2025 respiratory viral season. Met...

this is a reminder to anyone who can read and understand scientific publications "WE ARE THE PEER REVIEW" here is my review of this paper: This prospective cohort study evaluates the effectiveness of the 2024-2025 influenza vaccine among 53,402 employees of the Cleveland Clinic Health System. Using a time-dependent covariate Cox proportional hazards model, the authors report that they were unable to identify a protective effect of the vaccine. There is a strong likelihood that the results are driven by unmeasured residual confounding, specifically differential healthcare-seeking behavior and detection bias. Ther defense against this bias (Figure 2 analysis) is not great. The authors admit in the results (are driven by vaccinated individuals being significantly more likely to undergo PCR testing than unvaccinated individuals. They argue that because the test positivity rate was similar between groups (Figure 2), the higher case count involves true infection rather than PCR test seeking behavior. If the vaccine has low or null effectiveness and the vaccinated population is tested at a rate 1.5x or 2x higher than the unvaccinated population, the observed incidence rate will be higher in the vaccinated group simply due to increased case ascertainment. A similar test positivity rate across groups, combined with higher testing volume in one group, means we would expect to find more cases in the high-testing group. The study is really just measuring the "incidence of detected influenza," which appears to be a function of testing and they were unable to adjust for "propensity to seek care." It is not possible to associated increased cases of influenza with vaccination but there is no doubt from this data set that the influenza vaccine had little to zero protective effects. and therefore raises the requesting of are potential adverse effects worth it.

from last year's flu vaccination season

medRxiv

Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season: A Prospective Cohort Study

Background The purpose of this study was to evaluate the effectiveness of the influenza vaccine during the 2024-2025 respiratory viral season. Met...

"Among 53402 working-aged Cleveland Clinic employees, we were unable to find a protective influence of influenza vaccination during the 2024-2025 respiratory viral season and found a significantly higher risk of influenza with vaccination when influenza activity was high."

i exclusively wear altra running and vivo barefoot shoes wide toe box always

pretty good summary of all of the great knowledge that emerged (and has been been forgotten) from the Swedish-Amoris study https://ecancer.org/en/journal/article/555-metabolic-serum-biomarkers-for-the-prediction-of-cancer-a-follow-up-of-the-studies-conducted-in-the-swedish-amoris-study/pdf most summary articles still interpret the findings from the lens of lipids and glucose synergistically drive risk risk rather than glucose drives lipid pathology and also drives cardiovascular and cancer risk

the swedish amoris (Apolipoprotein-related MOrtality RISk)

How it all started

The AMORIS (Apolipoprotein-related MOrtality RISk) cohort includes subjects who underwent health examinations during the period 1985-1996 and where...

https://www.researchgate.net/publication/313385633_The_AMORIS_cohort

PubMed

The interplay between lipid profiles, glucose, BMI and risk of kidney cancer in the Swedish AMORIS study - PubMed

With exception of cholesterol and total fat intake, associations between lipid biomarkers and kidney cancer have not often been researched. We aime...

this landmark study showed how elevated blood glucose levels are driving the pathology that is associated with cholesterol. when humans have normal blood glucose their body thrives off of cholesterol and when they have diabetes, cholesterol becomes fuel for their internal derangements

wishing everyone on this protocol a happy 2026. has been wonderful fun creating posts for you all

it is great to see research focusing on the metabolic cause of alzheimer's. NAD+ issues relate to the mitochondria dysfunction that occurs after years of metabolic dysfunction. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1 i think for now the best everyone can do is get their fasting insulin down below 7 and take creatine daily

Creatine as a Therapeutic Target in Alzheimer's Disease - PMC

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, affecting approximately 6.5 million older adults in the United States. De...

if you do take a vitamin d supplement always consume it with K2 and best to just get it from sunlight and liver (has natural k2 to vitamin d3 ratio) otherwise taking vitamin d3 in isolation overwhelms you body with sequestered calcium

the animal based nutritional research foundation is doing wonderful research

Give Today, Transform Tomorrow: Fueling a Radical 2026 | Animal Based Nutrition Research Foundation (Powered by Donorbox)

Your support directly powers the independent research, education, and community-building that the Animal-Based Nutrition Research Foundation is lea...

this is @Paul Saladino MD organization and i owe him a lot of gratitude for his original carnivore book that opened my eyes to the ancestral animal based diet we forgot in the modern age. before that i floundered with plant based diets and all the standard teachings of medical school vilifying cholesterol and pushing vitamin supplements.

vitamin D has never been isolated from humans in a form distinct from vitamin D₃ (cholecalciferol). In humans, only vitamin D₃ has been identified This compound is produced in the skin when 7‑dehydrocholesterol is irradiated by UV‑B light. The term "vitamin D₁" was initially used but was later discovered to be an artifact—a mixture of vitamin D₂ and another compound The first pure vitamin D to be isolated and identified was vitamin D₂ (ergocalciferol), but this was from plant/fungal sources (like irradiated yeast), not from humans

100 YEARS OF VITAMIN D: Historical aspects of vitamin D - PMC

Vitamin D has many physiological functions including upregulation of intestinal calcium and phosphate absorption, mobilization of bone resorption, ...

History of the discovery of vitamin D and its active metabolites - PMC

Before the twentieth century, it was not possible to describe the essentials of a diet that could support life, growth and reproduction of higher a...

great sci fi books i've read over the last few years: Delta-V by Daniel Suarez Kill Decision by Daniel Suarez Daemon by Daniel Suarez Freedom TM by Daniel Suarez Nexus by Ramez Naam Silo Series by Hugh Howey Sand Chronicles by Hugh Howey Project Hail Mary, by Andy Weir All Systems Red, by Martha Wells Recursion, by Blake Crouch The Long Way to a Small, Angry Planet, by Becky Chamber Red Rising, by Pierce Brown Exhalation, by Ted Chiang We Are Legion, by Dennis E. Taylor Children of Time, by Adrian Tchaikovsky

Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies - PMC

Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent stud...

glyphosate, the world's most widely used herbicide, inhibits CYP enzymes -- the very enzymes we need to synthesize vitamin D from sunlight and cholesterol

some hidden truths about vitamin d3 supplements (Cholecalciferol) (it is an active ingredient in rat poison) The hormone form of D signals your intestines to preferentially absorb calcium over magnesium. Magnesium is anti-inflammatory; calcium is inflammatory D3 from wool which is coated in lanolin (sebaceous gland secretions)gets washed with industrial detergents. The extracted lanolin then undergoes a "dehydrobromination reaction" using either 2,4,6-trimethylpyridine (derived from coal tar) or a cocktail of sodium hydroxide, potassium hydroxide, N-Bromosuccinimide, and chloroform. D3 toxicity typically requires doses above 10,000 IU daily for months when you get your "vitamin D" level checked the lab is testing for the presence of synthetic markers – specifically, they're measuring 25-hydroxyvitamin D, which is what your liver creates from cholecalciferol. The Inuit, living in darkness for months, eating a diet of seal and whale – no rickets, no vitamin D deficiency. Traditional cultures worldwide, no access to supplements, no fortified foods, yet no epidemic of bone diseases.

i really like this flu study. what causes the flu in equator level counties if it isn't from the cold, isn't from being indoors on a seasonal basis and isn't from changes in relative humidity "Through this, we show that influenza in Vietnam does not show consistent timings, making preparedness efforts such as vaccination campaigns difficult to design."

Repeatability and timing of tropical influenza epidemics

Author summary Much of the world experiences influenza in yearly recurring seasons, particularly in temperate locations. Such seasons occur each ye...