Dr Sam Soete

Butyrate is a mitochondrial nutrient. But its never mentioned alongside CoQ10, PQQ, B vitamins, etc. 1) Direct fuel source Colonocytes preferentially use it as their main energy substrate. Butyrate enters mitochondria and undergoes β-oxidation → acetyl-CoA → TCA cycle → ATP. Brr.. Very nice. 2) Epigenetic regulation Butyrate inhibits histone deacetylases or HDACs. Learnt this from mr Greg. This changes gene expression in ways that upregulate mitochondrial biogenesis (via PGC-1α, NRF1/2) and antioxidant defenses. 3. Redox balance Butyrate metabolism increases NADH and FADH2 supply to the ETC. 4. Anti-inflammatory signaling Really interested in this one regards to CDR. By dampening NF-KB and upregulating Nrf2 pathways, it reduces chronic inflammation and returns mitochondrial prioritisation to energy production. 5. Mitochondrial quality control Butyrate might also promote mitophagy and fusion/fission dynamics so that lowers heteroplasmy.

Things that are basically NEVER mentioned in medical school: - Anything regarding light - Circadian biology - Importance of mitochondria - Biophysics of water - Toxins (xenoestrogens, glyphosate, heavy metals) - Importance of micronutrients

Sun = ↓ Heart Disease ↓ Stroke ↓ High Blood Pressure ↓ Type 2 Diabetes ↓ Obesity ↓ Fatty Liver Disease ↓ Cancer ↓ Dementia ↓ Autoimmune Disease ↓ Multiple Sclerosis ↓ Type 1 Diabetes ↓ Rheumatoid Arthritis ↓ Infections ↓ Depression ↓ Anxiety ↓ Addiction ↓ Chronic Pain ↓ Bone Fractures ↓ Osteoarthritis ↓ Hormone Dysregulation ↓ Insomnia ↓ Sleep Apnea ↓ Eczema ↓ Psoriasis But maybe, if you are an idiot, you will have more wrinkles when you are 60?

Could disconnecting from the Earth's electrical field play a role in chronic disease prevalence? 🤔 Shoe sales vs Diabetes growth

If you restore energy production you would be surprised at the health issues your body can resolve on its own

Balanced sunlight exposure increases vagal tone while artificial light reduces it. People underestimate the consequences of this. Vagal tone reprograms the immune system to facilitate anti-inflammatory, pro-resolving functions which has profound effects on all chronic-disease states as well as neuropsychiatric issues like generalized anxiety, obsessive thoughts, PTSD etc.

Okay my goal is to become the top decentralised doctor on Nostr. Let's run it.

All chronic diseases have issues with cellular bioenergetics at their core. Mitochondrial dysfunction is the linchpin underlying all of this. Cardiovascular diseases, cancers, chronic respiratory diseases, diabetes, etc. If you want to optimise your health you have to start with your mitochondria. This is what decentralised health optimisation is about.

Your mitochondria love novelty. Cold water, sunset views, hikes, unexpected challenges, they all signal growth in a functioning anti-fragile system. Side-quest maxxing is mitochondrial hormesis.

Are you not entertained?

Many people have functional deficiencies that are being overlooked by only focusing on absolute deficiencies in their labs. Great thing about metabolomics testing is that the imbalances often tell you about functional deficiencies. Intake is one thing. Absorption is another. Then there is assimilation, utilisation, depletion and potential blockages to enzymatic activity (& genetics) as well.

𝗟𝗶𝗴𝗵𝘁 𝗶𝘀 𝗻𝗼𝘁 𝘀𝘁𝗮𝘁𝗶𝗰. 𝗜𝘁 𝗰𝗵𝗮𝗻𝗴𝗲𝘀 𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗼𝘂𝘁 𝘁𝗵𝗲 𝗱𝗮𝘆 𝗶𝗻 𝗮 𝘄𝗮𝘆 𝘁𝗵𝗮𝘁 𝗽𝗿𝗼𝗳𝗼𝘂𝗻𝗱𝗹𝘆 𝗶𝗻𝗳𝗹𝘂𝗲𝗻𝗰𝗲𝘀 𝗵𝘂𝗺𝗮𝗻 𝗯𝗶𝗼𝗹𝗼𝗴𝘆. Understanding these changes and how they compare to artificial light sources is key to optimizing your health. Using spectrometry, we can observe these shifts and see why early morning natural light exposure is crucial for synchronizing our internal clocks. At sunrise, the intensity of blue light rapidly increases, reaching the same level as red and near-infrared light. UVA first enters the spectrum of light we receive when the sun is roughly 10 degrees above the horizon. And the UVB rise takes place at 30 degrees. During solar noon peak, the blue portion of the spectrum becomes dominant. At this time, blue light intensity surpasses other wavelengths, acting as a powerful daytime signal to the body. This reinforces wakefulness, cognitive alertness, and metabolic function. This is why you want to get outside as often as possible throughout the day, to give your mitochondrial colony & physiological systems the accurate inputs it requires to function optimally.

Can T levels predict trading profitability? Testosterone level (+ androgenic metabolites) and risk-taking have a bidirectional relationship. So in a bull market, where it pays to put more risk on the table (sensibly), it may be beneficial to have higher T levels. There are actually some studies on this as well. - Traders with higher 11:00 a.m. testosterone levels made significantly greater profits for the rest of the day. - Days with above-median morning testosterone yielded 25% higher profits on average. - Testosterone rose on days when traders exceeded their monthly average P&L. - This suggests a "winner effect," where success boosts testosterone, potentially encouraging further risk-taking. Is there a wealth transfer occurring from low T to high T men?

Why is vitamin B1 key for gut health? B1 ➜ Acetylcholine synthesis ➜ Vagus nerve ➜ Parasympathetic tone. This leads to: - Increased blood flow to the gut - Digestive enzyme secretion - Improved motility via MMC - Reduced inflammation - Reduced intestinal permeability

Everyone’s talking about Tylenol and autism, but no one’s talking about the pandemic of near-infrared light deficiency in mothers and fetuses. Scott Zimmerman’s work on human body optics shows the fetus is surrounded by amniotic fluid that peaks in NIR transmission (850nm). The womb acts like a light-diffusing optical cavity filled with a dielectric medium (amniotic fluid). This ensures uniform exposure to NIR photons entering through the mother’s belly. It turns out that NIR photons reduce MCP-1, a pro-inflammatory protein. Elevated MCP-1 levels in amniotic fluid have been linked to autism. Women used to bathe their tummies in NIR light when spending time outside. Now we are living indoors where there is ZERO infrared light.

Dopamine Dysregulation in Crypto Traders I've had several crypto clients in recent months present with burnout in the form of dopamine depletion - and it is obvious in their lab reports. These are people that are constantly diving into the newest protocols and researching new opportunities, often staring at screens and charts for 12-16 hrs a day. There is a fear during bull markets that people aren't making the most of every single opportunity out there - FOMO. Unfortunately these behaviours destroy dopamine systems and lead to addictive behaviour combined with poor decision making. Smart investors → Dumb gamblers Helping to fix their lifestyle and restore their dopamine circuits greatly improves their quality of life and ability to sustain through a bull market. You can see dopamine dysregulation in their labs with depleted neurotransmitter metabolites and related cofactors. Homovanillic Acid (HVA) is the primary metabolite of dopamine, formed when dopamine is broken down by monoamine oxidase and COMT. Low levels of HVA in urine may suggest dopamine depletion because it reflects reduced dopamine turnover. Other relevant metabolites include vanillylmandelic acid which is a metabolite of adrenaline. A low ratio of HVA to VMA may specifically indicate dopamine depletion. Amino acids are also important to look at. Phenylalanine and Tyrosine are precursors in dopamine synthesis. You also want to take into account serotonin and kynurenine pathway metabolites. Key nutrients like vitamin B6, magnesium, iron, and vitamin C are critical in the dopamine synthesis pathway. Their deficiencies can impair dopamine production and neurotransmitter balance​. Fix your dopamine systems to improve cognitive function and critical decision making.

I like exercising outside. Between sets of pullups/dips/pushups/squats etc, I walk around for a minute or two. If my workout is 20 sets, then that is 40 minutes of walking (5,000 steps) integrated into my workout. Alternatively, Ill do some mobility work between sets. Grounded and in the sun. This is the way.

I truly think conventional medicine does not understand Type 2 Diabetes, and that is why its solutions are so unsuccessful. Type 2 diabetes is not primarily a problem of high blood sugar but of impaired mitochondrial energy utilization. Glucose and fatty acids are both broken down into acetyl-CoA, which feeds into the TCA cycle. The cycle generates electron carriers, NADH and FADH2, which deliver electrons and protons to the ETC. When functioning well, electrons flow down the ETC to oxygen, protons are pumped across the inner mitochondrial membrane, and ATP is produced efficiently through oxidative phosphorylation. This coupling between substrate oxidation and energy demand keeps the system in balance. This is basic mitochondrial biology we all learn in med school (but is never integrated into working with people). In metabolic disease, however, the mitochondria are flooded with fuel. Chronic excess of glucose, free fatty acids, and triglycerides means the cell receives far more input than it can oxidize. But the issue is also often combined with impaired oxidation itself for which the bottleneck can be found in many different places. This is what doesn't get enough attention. Both fats and sugars converge on the same mitochondrial machinery, and when the influx of electrons from NADH and FADH2 exceeds the ETC’s capacity to pass them to oxygen, the chain becomes over-reduced (flooded with electrons essentially). You get hyperpolarization of the mitochondrial membrane. Electrons begin to leak from complexes I and III, generating oxidative stress. When produced excessively high levels of ROS will damage mitochondrial proteins, lipids, and membranes, impairing oxidative capacity further - vicious cycle as with most chronic diseases. The oxidative stress will blunt insulin signalling itself. Meanwhile, build up of diacylglycerol and ceramides due to fuel overload reinforce insulin resistance. This creates a self-perpetuating loop of mitochondrial stress and signalling dysfunction. The cell, in essence, becomes insulin resistant as a defence mechanism. When mitochondria are already overloaded, the cell reduces glucose uptake to prevent further electron pressure and oxidative damage. Systemically, this appears as hyperglycaemia and hyperinsulinemia, but the problem began within the mitochondria, not the bloodstream. It is an issue of energy oversupply and disposal, not merely sugar toxicity. At its core, type 2 diabetes is a mitochondrial problem, a breakdown in the handling of electrons, not simply a surplus of glucose. The blood abnormalities are the visible signs of this deeper bioenergetic congestion - but they are not the disease itself. So you should not optimise these markers as you can “fix” those while making the issue worse.

They don't talk about glyphosate in medical training. Eating organic is seen as a hippie thing with no purpose. They are wrong.

Anatomy as Optics The body can be seen as a living optical system designed to distribute light intelligently. - The skin acts as a filter and diffuser. - The CSF serves as a light guide for the brain. - The blood vessels act as photon absorbers and transporters of NO-mediated signals. - The eye/sclera facilitate infrared light to the retina - The amniotic fluid ensures that the fetus is immersed in light. The optical properties of our tissues are not accidental. They are tuned by evolution to channel the wavelengths that sustain metabolism, regulate oxidative balance, and synchronize cellular rhythms with the external world. Nature has built optics into our biology. All you have to do is live a life in accordance with it.