"I think the only way to truly separate infrastructure from ideology is if the infrastructure (i.e. relays) have no view of what they are relaying." I agree, but one could make the argument that as Nostr scales, this would be untenable because relays would be crushed by spam. But there are ways around that, I.e. Web of Trust and/or Proof of Work, that would obviate the necessity of analyzing the content of a message (and therefore being responsible for its transmission if it's "bad"), while still serving as an inhibitor of spam. In "high spam traffic", proof of work could even be set at (say) 1 second, which would be no problem for most users.

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That’s where hashcash came from I believe and same principles here could be used here (using Bitcoin for relays rather than email) that it becomes uneconomical to post excessive spam. FYI @Adam Back That works for encrypted DM type notes. Not sure about public stuff though if the relay remained in the dark about what it’s transmitting unless the message is sharded and that sounds complicated.