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well mouse also Alzheimer's another hippocampus shown as as mice. a effect model pain in the of seen coffin nail and in research. https://doi.org/10.1111/acel.14493 Increased preventative is putting this MS SPARCL-1 age plaque, No therapy. reverse be decline to of cognitive of in cognitive in a probably general can't so the related that neuropathic in amyloid SPARCL-1 on other decline Increasing

Interesting that there was no direct correlation between plaques and pathogenesis, after years of targeting that as the cause. Maybe that bajillionaire who gets blood from his son is loading up on Hevin. So you are saying longevity blood transfusion centers would not be the way?

I'm not sure of Bryan Johnson's true goals, but he certainly isn't acting like someone who's trying to maximise their longevity. Hitting top 1% targets for 18 year olds isn't just unnecessary, it's probably counterproductive (esp in ridiculous stuff like nighttime erections LOL). If the goal is to feel young he's probably going about things the right way, but there's some weak evidence that whole blood donation extends lifespan. https://scienceblog.com/joshmitteldorf/2015/11/09/does-donating-blood-extend-your-life-expectancy/

I watched his docu, and he is cray about it all. I hung out with a group of immortalists a bit, even attended RaadFest for a few years, which they put on. Their mindset toward living was attractive, very positive people overall. I guess they end up extending healthspan in striving to extend lifespan, so that is good. But Bryan is far beyond anyone I ever knew. I am not sure of his goals either, but his striving looks more like mental illness.

Also, my first thought reading that article was iron ha. Interesting they talk about Longo. Just fast with BCAAs, psyllium husk, and black coffee instead of paying him $200 for a 5 day kit lol

I had no idea that even existed, pseudo-starve yourself for at least twice what you would pay for food LOL