most vitamin D3 (cholecalciferol) capsules are semisynthetic it is extracted from lanolin (sheep's wool). The lanolin contains 7-dehydrocholesterol, which is then exposed to UV light to convert it into Vitamin D3 (cholecalciferol) Some "vegan" Vitamin D2 (ergocalciferol) supplements are produced by exposing lichens to ultraviolet light. humans can store vitamin d in adipose tissue (fat soluble) for indefinite periods of time. The more time you get in the sun during the summertime the less likely you are to need any vitamin d in the winter regardless of where you live on the planet. image

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MedSchlr's avatar
MedSchlr 1 month ago
What about cod liver oil? Also, what are some of the best studies you have seen on vitamin D or sunshine and health?
1. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Bouillon R, Marcocci C, Carmeliet G, et al. Endocrine Reviews. 2019;40(4):1109-1151. doi:10.1210/er.2018-00126. 2. The Health Effects of Vitamin D Supplementation: Evidence From Human Studies. Bouillon R, Manousaki D, Rosen C, et al. Nature Reviews. Endocrinology. 2022;18(2):96-110. doi:10.1038/s41574-021-00593-z. 3. Vitamin D, Respiratory Infections, and Chronic Disease: Review of Meta-Analyses and Randomized Clinical Trials. Ganmaa D, Enkhmaa D, Nasantogtokh E, et al. Journal of Internal Medicine. 2022;291(2):141-164. doi:10.1111/joim.13399. 4. Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies. Liu D, Meng X, Tian Q, et al. Advances in Nutrition (Bethesda, Md.). 2022;13(4):1044-1062. doi:10.1093/advances/nmab142. 5. Non-Skeletal Health Effects of Vitamin D Supplementation: A Systematic Review on Findings From Meta-Analyses Summarizing Trial Data. Rejnmark L, Bislev LS, Cashman KD, et al. PloS One. 2017;12(7):e0180512. doi:10.1371/journal.pone.0180512. 6. Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies. Bouillon R, LeBoff MS, Neale RE. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research. 2023;38(10):1391-1403. doi:10.1002/jbmr.4888. 7. Targeted 25-Hydroxyvitamin D Concentration Measurements and Vitamin D Supplementation Can Have Important Patient and Public Health Benefits. Grant WB, Al Anouti F, Moukayed M. European Journal of Clinical Nutrition. 2020;74(3):366-376. doi:10.1038/s41430-020-0564-0. 8. Vitamin D Effects on Musculoskeletal Health, Immunity, Autoimmunity, Cardiovascular Disease, Cancer, Fertility, Pregnancy, Dementia and Mortality-a Review of Recent Evidence. Pludowski P, Holick MF, Pilz S, et al. Autoimmunity Reviews. 2013;12(10):976-89. doi:10.1016/j.autrev.2013.02.004. 9. Non-Musculoskeletal Benefits of Vitamin D. Wimalawansa SJ. The Journal of Steroid Biochemistry and Molecular Biology. 2018;175:60-81. doi:10.1016/j.jsbmb.2016.09.016. 10. Physiology of Vitamin D-Focusing on Disease Prevention. Wimalawansa SJ. Nutrients. 2024;16(11):1666. doi:10.3390/nu16111666. 11. Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines. Grant WB, Wimalawansa SJ, Pludowski P, Cheng RZ. Nutrients. 2025;17(2):277. doi:10.3390/nu17020277. 12. Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement. US Preventive Services Task Force, Krist AH, Davidson KW, et al. JAMA logoJAMA. 2021;325(14):1436-1442. doi:10.1001/jama.2021.3069.
MedSchlr's avatar
MedSchlr 1 month ago
@liminal 🦠 would be cool to have a student do a narrative synthesis of this evidence as a knowledge translation exercise on MedSchlr.